Доцільність Корекції Латентного Дефіциту Заліза В Лікуванні Школярів Із Дисфункцією Жовчного Міхура Та Сфінктера Одді

Abstract

Background. Rates of iron deficiency (ID) remain high among children in Ukraine. ID contributes to burdened gastrointestinal pathology in children and adolescents, but evaluation of the impact of ID correction on the biliary tract dysfunction course is currently lacking. The objective was to determine the impact of latent ID correction on the clinical course of gallbladder and sphincter of Oddi dysfunction (GSOD) and iron status in schoolchildren. Materials and methods. A case-control study was conducted in 60 children aged 9-17 years, who had been undergoing the in-patient treatment for GSOD exacerbation and had latent ID. Children were divided into 2 groups: I-30 patients treated with iron supplementation (50 mg elemental iron) daily for 125 days; II-30 children having no iron supplementation. The study of anamnesis, clinical examination, complete blood count, determination of serum iron, transferrin saturation calculation, hair microelement profile evaluation, follow-up for 12 month were performed. Results. The study found that the use of iron supplement in children with GSOD and latent ID not only compensates ID in them, but also facilitates the GSOD course lowering the incidence of GSOD exacerbations by 30.7 %. Conclusions. Latent ID correction with combined iron, copper and manganese gluconate supplement facilitates the clinical course of GSOD and improves iron status in schoolchildren.