The paper presents the results of a scoping study of the possibility of applying various practices of agricultural production adaptation to existing and potential climatic changes to the conditions of the West Siberian economic region. It is assumed that already in the medium term, the agro-industrial complex of the macro-region will face new defining challenges in terms of climate change impact on everyday production processes and the need to respond by developing sustainable strategies to overcome them and adapt to them. The concept of agriculture as a climateresponsible sector is introduced. In this regard, the possibility of developing a unified adaptation mechanism for agriculture in Siberian regions through a combination of economic, research and social practices while maintaining familiar forms and tools of production is considered. In addition, the main barriers to adaptation of the agro-industrial complex of Western Siberia to climate change are presented, and comments are given on possible ways to overcome them while maintaining the growth rate of the industry and the nature of economic activity, including in regions with traditional forms of management.