Изучение Противовоспалительных, Иммуномодулирующих И Противоопухолевых Свойств Снк-411

Коваленко, Л. П.; Никитин, С. В.; Kuznetsova, O. S.; Журиков, Р. В.; Сорокина, Александра Валериановна; Мирошкина, Ирина Александровна; Коржова, К. В.

doi:10.30906/0869-2092-2018-81-5s-115-115a

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“…При развитии раневой инфекции в эксперименте наблюдалось снижение уровней IL-4 и IL-10 по сравнению с контролем I на 10% (р > 0,05) и 26% (р < 0,05) соответственно. Введение пиримидинового соединения и препарата [3,8,12,13]. Следует отметить, что выраженное воздействие производного пиримидина относительно препарата сравнения на уровни интерлейкинов может быть связано с бактериостатическим действием исследуемого соединения, так как усиление интоксикации при быстрой гибели микроорганизмов в результате воздействия бактерицидных средств может усугублять течение инфекционновоспалительного процесса [15,16].…”

Section: результаты и обсуждениеunclassified

Effect of a pyrimidine derivative on the level of cytokines in conditions of streptococcal wound infection

Tsibizova,

Yasenyavskaya,

Tyurenkov

et al. 2023

Med. immunol.

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Diseases caused by Streptococcus pyogenes are one of the significant problems of practical health care, due to the ability of this pathogen to cause morbidity in all age groups of the population with the development of different complications. The streptococcal infection is accompanied, along with infectious and inflammatory symptoms, by a pronounced immune response to Streptococcus pyogenes, which is mediated by the functional activity of monocytes and dendritic cells responsible for the production of pro- and anti-inflammatory cytokines that regulate the interaction, proliferation and functional activity of all participants in the cellular and humoral links of immunity. The purpose is to study the effect of a pyrimidine derivative on the level of pro- (IL-1β, IL-6, IL-8) and anti-inflammatory interleukins (IL-4, IL-10) in conditions of experimental streptococcal wound infection. The study of the effect of the pyrimidine derivative 3-[2-[(4,6-dimethylpyrimidin-2-yl) amino]-2-oxoethyl]quinazolin-4(3H)-one was carried out in vivo on the model streptococcal wound infection. The experiments were carried out on CBA mice 3 months old (20-22 g). Animals were divided into groups: control I–healthy animals, which were injected with water for injection; control II–infected untreated animals; experience I – animals that were treated intraperitoneally with a pyrimidine derivative at a dose of 36 mg/kg for 7 days, starting from the first day of infection; experiment II – animals that were treated intraperitoneally with the reference drug cefepime at an average therapeutic dose of 50 mg/kg in the same regimen as the test compound. The levels of pro- and anti-inflammatory interleukins in blood serum were determined by enzyme immunoassay. The study found that the pyrimidine derivative 3-[2-[(4,6-dimethylpyrimidin-2-yl)amino]-2-oxoethyl]quinazolin-4(3H)-one under conditions of streptococcal wound infection has an immunoregulatory effect, manifested in a decrease in pro-inflammatory and an increase in anti-inflammatory interleukins.

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Section: результаты и обсуждениеunclassified

Effect of a pyrimidine derivative on the level of cytokines in conditions of streptococcal wound infection

Tsibizova,

Yasenyavskaya,

Tyurenkov

et al. 2023

Med. immunol.

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Изучение Противовоспалительных, Иммуномодулирующих И Противоопухолевых Свойств Снк-411

Abstract: Материалы V съезда фармакологов России «Научные основы поиска и создания новых лекарств» (14-18 мая 2018 года, г. Ярославль)

Cited by 1 publication

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Effect of a pyrimidine derivative on the level of cytokines in conditions of streptococcal wound infection

Effect of a pyrimidine derivative on the level of cytokines in conditions of streptococcal wound infection

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