К Вопросу О Профилактике Патологии Молочных Желез

Татарчук, Т. Ф; Ефименко, О. А.

doi:10.18370/2309-4117.2012.8.10-16

Cited by 5 publications

(6 citation statements)

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“…Доброякісні зміни ГЗ належать до найбільш поширених захворювань у жінок різних вікових груп. У 76-97,8% жінок репродуктивного віку з нейроендокринними гінекологічними захворюваннями виявлена патологічна перебудова ГЗ [18,19]. У жінок, які мають нерегулярний менструальний цикл переважно за типом олігоменореї, ураження ГЗ відзначається в 64,5% випадків; при гінекологічних захворюваннях, які супроводжуються дисфункціональними матковими кровотечами, -у 57,6%;…”

Section: гінекологіяunclassified

“…Особливе місце серед них займає дует міоми матки і ГЗ. Дані різних досліджень свідчать про те, що внаслідок дефіциту прогестерону відбувається морфофункціональна перебудова і матки, і ГЗ [19,[21][22][23]. Якщо в матці ці процеси супроводжуються гіперплазією ендометрія, то в ГЗ -набряком і гіпертрофією внутрішньочасточкової сполучної тканини, а надлишкова проліферація епітелію проток, яка призводить до їхньої обструкції, при збереженій секреції в альвеолах призводить до збільшення і розвитку кістозних порожнин [24,25].…”

Section: гінекологіяunclassified

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Current state of problem of disturbances of menstrual function at women with diffuse dysplasia of mammary glands

Гладенко

2021

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Diffuse benign dysplasia of the mammary glands is one of the frequent pathologies that practitioners almost daily encounter. Studying the mechanisms of development of pathological gynecological conditions, the researchers concluded that there is a pathogenetic connection between cyclic changes in the reproductive system and the physiological processes occurring in the mammary glands. This makes it possible to assume a high probability of occurrence of pathological changes in the mammary glands in various gynecological diseases, developing as a result of disorders of the hypothalamic-pituitary-ovarian system. The general inhibition and unity of the reaction of the reproductive organs to hormonal imbalance is the main prerequisite for the development of benign hyperplastic and the risk of malignant processes. The relevance of studying the reproductive health of patients with dyshormonal non-inflammatory pathology of the genital organs is due to the steady increase in the proportion of this pathology in recent years in the structure of gynecological morbidity, the rejuvenation of the patient population, and the lack of a single algorithm for rehabilitation measures. On the one hand, effective treatment reduces symptoms, guarantees quality of life, on the other hand, mastopathy is a risk factor for the development of a malignant tumor in the future. Therefore, timely correction of dysplasia can be considered as a variant of primary prevention of breast cancer. The choice of an adequate tactic to manage such patients from the existing variety of dosage forms is the key to the success of treatment.

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Section: гінекологіяunclassified

Current state of problem of disturbances of menstrual function at women with diffuse dysplasia of mammary glands

Гладенко

2021

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“…Доказана связь циклической формы масталгии с повышенным риском РМЖ. В частности, в крупном когортном исследовании, проведенном во Франции, было показано, что у женщин, страдавших от циклической масталгии более 3 лет и не получавших лечения, риск РМЖ был повышен в 5 раз по сравнению с женщинами, ее не имевшими (относительный риск 5,31; 95% доверительный интервал 1,[5][6][7][8]4) [28].…”

Section: классификацияunclassified

“…На фоне гинекологической патологии доброкачественные заболевания МЖ (ДЗМЖ) встречаются у 76-97,8% женщин [5,6], и гинекологическая заболеваемость у этого контингента составляет 115%, т. е. на каждую женщину с заболеванием МЖ приходится более одного гинекологического диагноза [5,6]. Наиболее часто мастопатия сочетается с гиперпластическими процессами в органах репродуктивной системы: гиперплазия эндометрия -52%, аденомиоз -44%, эндометриоз -82%, миома матки -63%; при доброкачественных опухолях и опухолевидных заболеваниях яичников -в 70% случаев [4,6,7]. МОЛОЧНАЯ ЖЕЛЕЗА -ЧАСТЬ РЕПРОДУКТИВНОЙ СИСТЕМЫ ЖЕНЩИНЫ В МЖ высока концентрация цитозолевых тканевых рецепторов к стероидным соединениям, благодаря чему они, как и другие органы репродуктивной системы женщины, восприимчивы к 15 гормонам.…”

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Mastоpathy is a biomarker of hormonal distress. Literature review

Ermolenko

Прутиян

2020

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Mastopathy is an extensive heterogeneous group of the mammary glands pathologies, varying in its manifestations and in degree of breast cancer risk. The prevalence of mastopathy in female population is 60–80%, and this pathology has an age-related epidemiological features. On the background of gynecological diseases benign breast diseases occur in 76–97.8% of women. Frequency of mastopathy is reduced with the onset of menopause, while the risk of malignant transformation increases. Breast tissue has a high concentration of cytosolic tissue receptors to steroid compounds, so like other organs of women’s reproductive system it is susceptible to 15 hormones. Estrogen concentration in the breast connective tissue in 2–20 times higher than in blood plasma. Decisive role in the emergence of breast pathology belongs not to the absolute concentrations of hormones in blood plasma, but condition of sex steroids receptors in breast tissue. Mastodynia is a reflection of functional changes and response of breast tissue to hormonal imbalance. Proliferative mastopathy without atypia and with atypia significantly increase the risk of breast cancer. Progesterone deficiency is a key factor in the pathogenesis of dishormonal breast diseases.For timely prevention, early diagnosis of breast diseases and breast cancer, prognosis and treatment tactics, mammography, MRI and ultrasound of the gland are used, as well as various biological markers (tissue, cellular and molecular) determination, steroid hormone receptors, various growth factors and their receptors are evaluated.The timely appointment of transdermal gel Progestogel® eliminates mastodynia and other symptoms of mastopathy, and is pathogenetic treatment, which prevents the transition of functional disorders into morphological in mammary glands, reduces mammographic breast density, and thus reduces oncology risk.Thus, prevention, early diagnosis, timely pathogenetic treatment of dishormonal breast diseases reduces the risk of breast cancer.

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“…• по-перше, у частини пацієнток розвиток захворювання супроводжується вираженою клінічною симптоматикою, що знижує якість їх життя; • по-друге, проліферативні форми ДГЗ є чинниками ризику для розвитку раку грудної залози, а ММ може трансформуватися у рак тіла матки [1][2][3][4]. Дана інформація формує психологічну напруженість пацієнток, призводить до проведення багаточисельних обстежень, повторних курсів комплексного консервативного лікування, оперативних втручань.…”

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Women have features of diagnostics and treatment of dysplasia of mammary glands and violations of menstrual function with a hysteromyoma

Gladenko

2023

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The objective: A research purpose is the development and introduction of a tactic of diagnostics and treatment of dysplasia of mammary glands and violations of menstrual function for women with a hysteromyoma. Materials and methods. The differentiated going was developed near the treatment of patients with the united diseases of mammary glands and hysteromyoma, which consisted of a few stages. In the first stage complaints, and anamnesis was analyzed, an objective review, gynecological review, and palpation of mammary glands were conducted and as a result, there was an individual plan of inspection of every sick. In the second stage in accordance with a mine-out plan complex inspection, which includes the laboratory and instrumental methods of research, and tests of functional diagnostics, was conducted. In the third stage the results of inspection were analyzed, the correction of somatopathies was conducted, appeared contra-indication to that or other methods of treatment, surgical treatment of noncommunicative forms of dysplasia of mammary glands and violations of menstrual function was conducted for women with a hysteromyoma. In 1 group, the noncommunicative forms of diffuse dysplasia of mammary glands had 49 (76,7%) from 64 women, and diffuse mastopathy is the third – 14 (23,7%). In 2 groups the key form of mastopathy prevailed also – 73,3%, diffuse forms met in 26,7%. Results. The choice of the tactic of hormonal treatment was conducted taking into account a gynecological disease, state of mammary glands, presence and volume of operative interferences, and endocrine violations. Herbal medicines, mainly, were appointed additionally with the purpose of normalization of secretion of prolactin. At the setting of hormonal preparations, the results of tests of functional diagnostics were taken into account and information hormonal research, with anovulatory cycles and insufficiency of luteal phase progestogens was appointed patients and the combined oral contraceptives, at a normal-diphasic cycle – only the combined oral contraceptives. At contra-indications to the setting of hormonotherapy in all groups transdermally progesterone was appointed for 2,5 gs on the skin of every suckling gland 2 times per day (in the morning and in the evening) continuously during 6 months. The combined oral contraceptive advantage gave oneself up the gestagen of 3rd generation of desogestrel, which contains, gestodene, norgestimate. Preparations were used on a contraceptive chart for one year, beginning from the first day of the menstrual cycle. A positive therapeutic effect was considered on the following signs: from the side of mammary glands: diminishing of pain syndrome, a decline of oedematous ness of fabrics, diminishing of engorgement of mammary glands in a premenstrual period; from the side of privy parts: absence of complaints, pathological excretions and violations of the menstrual cycle. Analyzing the efficiency of the complex developed by us it follows notices, that for women with the United, pathology was succeeded on 43,4%, to conduct the prophylaxis of progress to the relapse of dysplasia of mammary glands and on 36,7% – violations of menstrual function for women with a hysteromyoma. Conclusion. Got information, in our view, convincingly testify that a conservative solitary of women who suffer illnesses of mammary glands in combination with a hysteromyoma is a prophylactic measure in relation to progress and relapse of the united pathology at this category of patients. It is got by us results give a right to recommend the offered complex in practical health protection to us.

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К Вопросу О Профилактике Патологии Молочных Желез

Cited by 5 publications

References 1 publication

Current state of problem of disturbances of menstrual function at women with diffuse dysplasia of mammary glands

Current state of problem of disturbances of menstrual function at women with diffuse dysplasia of mammary glands

Mastоpathy is a biomarker of hormonal distress. Literature review

Women have features of diagnostics and treatment of dysplasia of mammary glands and violations of menstrual function with a hysteromyoma

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