Кишечный Микробиом И Остеоартрит

Gubska, Olena; Kuzminetes, А.А.; Hutsul, V.M.; Lavrenchuk, Iryna

doi:10.22141/2308-2097.53.2.2019.168988

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…This variation can be explained by other factors, including intestinal microbiota composition. Our other investigation highlights this problem [21].…”

Section: Discussionmentioning

confidence: 59%

Comparing of Faecal Calprotectin Levels in Patients With Osteoarthritis Taking Nsaid Treatment and Patients Without Nsaids Therapy

Gubska

Kuzminets

Панін

2020

EUREKA: Health Sciences

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Faecal calprotectin (FC) level can be increased in several conditions, which are characterised by neutrophilic inflammation. Some medications, particularly NSAIDs, can elevate its level as well. NSAIDs are taken by patients in many chronic conditions, including osteoarthritis (OA). On the other hand, there is growing evidence that osteoarthritis is not only a degenerative disease, but it has a significant inflammatory component. The role of systemic inflammation is well-known in inflammatory joint diseases, but there is some evidence that it can play an essential role in the OA as well. It can suggest that in the OA, the inflammatory changes could be found in the different organs and systems. The aim of this study was to investigate the FC level in patients with osteoarthritis depending on the NSAIDs intake and to compare it to the FC levels in healthy adults. Materials and methods. In this small observational study, we evaluated the FC levels in patients suffering from OA (36 persons), divided them into two groups depending on their NSAIDs intake, and compared it to FC levels in healthy participants (12 persons). We compared the FC levels depending on the selectivity of the NSAIDs taken by our participants, as well. Results. The median calprotectin level in our patients was 72.57 (IQR 20.55-221.57) mg/kg, 95 %CI 26,18-109.01. OA patients had higher levels than the healthy group (p<0.001). OA patients who took NSAIDs had the highest FC levels – 221.57 (IQR 91.56-448.61) – higher, than those who did not take it – 72.57 (IQR 35.26-164.79) (p=0.03) and than healthy participants, who has normal FC levels (p<0.001); the FC levels of patients who did not take NSAIDs also exceeds healthy subject’s levels (p<0.001). The FC levels in the collective group have a sufficient positive correlation with the duration of NSAIDs intake, VAS score and strong correlation with Lequesne index values. We found that both NSAIDs groups have a significantly greater prevalence of elevated or high FC levels than the control group (p<0.001) and that NSAIDs patients significantly more often have high FC levels than those who do not take NSAIDs (p=0.035). When comparing FC levels in patients depending on the type of NSAIDs they take, we found that those who take non-selective NSAIDs has significantly higher FC levels than those who do not take NSAIDs – 264.1 (IQR 89.72-464.67) to 25.65 (IQR 19.5-75.33) (p=0.0003). The FC levels of who take selective NSAIDs – 98.53 (91.56-105.5) – did not differ significantly to non-selective NSAIDs taker’s group values and non-selective NSAIDs taker’s values (p>0.05). Conclusions. Patients who suffer from OA have higher FC levels than healthy individuals, and patients with OA who take NSAIDs regularly have higher FC levels than those who do not. The intake of non-selective NSAIDs is associated with higher FC levels, than the intake of high-selective NSAIDs. FC levels of those who take high-selective NSAIDs do not differ statistically from those who do not intake NSAIDs. Further research is needed in this area.

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“…This variation can be explained by other factors, including intestinal microbiota composition. Our other investigation highlights this problem [21].…”

Section: Discussionmentioning

confidence: 59%

Comparing of Faecal Calprotectin Levels in Patients With Osteoarthritis Taking Nsaid Treatment and Patients Without Nsaids Therapy

Gubska

Kuzminets

Панін

2020

EUREKA: Health Sciences

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“…Власне тому вивчення кишкового мікробіоценозу є надзвичайно актуальною темою, оскільки мікробіома людини як у здоровому стані, так і за різних патологічних станів тісно пов'язана з організмом господаря (Hubska et al, 2019).…”

Section: вступunclassified

The effect of the developed composition of lactic acid bacteria isolated from Carpathian cheese, on the body of laboratory animals

Kushnir¹,

Tsisaryk²

2021

SMLNUVMBA

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Data on the study of the effect of a consortium of lactic acid bacteria on the morphological parameters of blood and the state of the intestinal microflora of white rats using a composition of probiotic strains of L. lactis, Lb. plantarum and E. durans SB18 in a ratio of 50:40:10. Thus, when determining the morphological parameters of the blood of rats at 14 days of use found a positive effect of probiotic strains of lactic acid bacteria on the hematopoietic function of laboratory animals. In particular, a significant increase in hemoglobin concentration, erythrocyte count, leukocyte count and hematocrit value was found by 14.9, 14.0, 22.5 % (P < 0.05) and 5.7 %, respectively, compared with the control group. In addition, the use of the drug for 14 days caused an increase in the average concentration of hemoglobin in the erythrocyte (MCНS) by 9.8 % (P < 0.05) and a tendency to decrease the average hemoglobin in the erythrocyte (MCН) and the average erythrocyte volume (MCV) by 0.45 and 9.0 %, respectively, compared with the control group. Both central and peripheral organs of the immune system were also significantly affected. In particular, the relative weights of the thymus and spleen increased by 21.1 (P < 0.05 ) and 9.8 % (P < 0.05), respectively. When determining the leukogram of peripheral blood of rats, it was found that the use of the study drug in animals of the experimental group caused a tendency to increase the number of neutrophils, lymphocytes and monocytes by 6.0, 0.5 and 19.8 %, respectively, with a slight decrease in eosinophils. The use of a composition of a consortium of lactic acid bacteria stimulated an increase in lacto- and bifidobacteria content of the large intestine of white rats. In particular, a significant increase in the number of bifidobacteria and lactobacilli was found by 4.3 and 5.2 % (P < 0.001), respectively, relative to the animals of the control group. In addition, 14-day application of the studied composition of probiotic strains contributed to a probable reduction in the number of opportunistic and putrefactive microflora. The number of Escherichia coli, Staphylococcus aureus and fungi of the genus Candida significantly decreased relative to control by 4.7 (P < 0.01), 2.6 (P < 0.05) and 13.3 % (P < 0.001), respectively, all this indicated the recovery of the body of laboratory animals. The positive effect of lactic acid bacteria of the formed composition persists until the 21st day of the experiment.

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“…Высококалорийная диета неблагоприятно сказывается на барьерных свойствах слизистой оболочки желудочно-кишечного тракта (ЖКТ), способствует нарушению ее целостности, понижению продукции антимикробных пептидов и муцинов. Кроме того, изменяется микрофлора кишечника, возрастает продукция провоспалительных метаболитов, в частности липополисахаридов (ЛПС) [15]. Повышенная проницаемость кишечной стенки обеспечивает избыточное поступление ЛПС в системную циркуляцию, которая поддерживает хроническое низкодифференцированное воспаление в организме с активацией компонентов врожденного иммунитета через Toll-подобные рецепторы (TLRs) 4 [16].…”

Section: дислипидемияunclassified

The role of metabolic syndrome in the pathogenesis of knee osteoarthritis: a new view on the problem

et al. 2021

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На сегодняшний день получены многочисленные данные, неоспоримо доказывающие взаимосвязь остеоартроза (ОА) с метаболическим синдромом.При гиперлипидемических состояниях свободные жирные кислоты аномально накапливаются в тканях суставов. Это оказывает липотоксическое действие, что приводит к дисфункции клеток и их гибели. Пальмитаты и стеараты вызывают выраженное проапоптотическое действие на хондроциты суставного хряща.Факторы системной воспалительной реакции, продуцируемые жировой тканью, выступают в качестве значимого звена в патогенезе метаболического ОА коленного сустава. Метаболические нарушения, инсулинорезистентность, дислипидемия способствуют увеличению продукции медиаторов воспаления, гликированных соединений, образованию кислородных радикалов, провоцирующих эндотелиальную дисфункцию.Локальным звеном в патогенезе метаболического гонартроза является взаимосвязь внутрисуставных структур (суставного хряща, синовиальной оболочки, субхондральной кости и синовиальной жидкости) с внутрисуставной инфрапателлярной жировой клетчаткой. Доказано, что инфрапателлярная жировая клетчатка значительно увеличивается у пациентов с ожирением. Из-за близкого расположения с суставным хрящом и синовиальной оболочкой, жировая ткань находится с ними в тесном контакте. Под влиянием системных метаболитов, разрастаясь, адипоциты, преадипоциты, макрофаги, фибробласты и другие клетки жировых тел усиливают продукцию и высвобождение адипокинов, таких как лептин, адипонектин, висфатин, цитокинов, которые стимулируют асептическое воспаление, приводящее к развитию синовита, дегенерации хряща и прогрессированию гонартроза.Таким образом, метаболический синдром оказывает негативное влияние на состояние тканей сустава, способствуя возникновению гонартроза или его прогрессированию, реализуясь как через системные эффекты, так и за счет локального воздействия гипертрофируемой инфрапателлярной жировой клетчатки на компоненты синовиальной среды сустава.Ключевые слова: метаболический синдром, остеоартроз, дислипидемия, адипокины, оксидативный стресс, жировые тела Гоффа.Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.Источник финансирования: Авторы заявляют об отсутствии финансирования.

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Кишечный Микробиом И Остеоартрит

Cited by 4 publications

References 13 publications

Comparing of Faecal Calprotectin Levels in Patients With Osteoarthritis Taking Nsaid Treatment and Patients Without Nsaids Therapy

Comparing of Faecal Calprotectin Levels in Patients With Osteoarthritis Taking Nsaid Treatment and Patients Without Nsaids Therapy

The effect of the developed composition of lactic acid bacteria isolated from Carpathian cheese, on the body of laboratory animals

The role of metabolic syndrome in the pathogenesis of knee osteoarthritis: a new view on the problem

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