Мышиные Модели Сепсиса И Септического Шока

Korneev, Kirill V.

doi:10.1134/s0026898419050100

Cited by 22 publications

(1 citation statement)

References 172 publications

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“…Here, direct evidence of the involvement of lncRNAs in SICD is summarized ( Figure 2 ). This evidence is based on the findings from basic molecular biological research using animal models of hypodynamic septic shock induced by LPS and cecal ligation and puncture (CLP) ( 27 ); cardiac muscle cell lines (primary culture cardiomyocytes, H9C2, HL-1, and AC-16 cell lines) and microvascular cell lines exposed to serum from septic patients or administered with LPS ( 28 ); and clinical studies of sepsis patients subjected to cardiac dysfunction ( Table 1 ).…”

Section: Lncrna Involved In Sicd Among Various Cell Typesmentioning

confidence: 99%

The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction

Zhang

et al. 2021

Front. Cardiovasc. Med.

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Sepsis is a syndrome with life-threatening organ dysfunction induced by a dysregulated host response to infection. The heart is one of the most commonly involved organs during sepsis, and cardiac dysfunction, which is usually indicative of an extremely poor clinical outcome, is a leading cause of death in septic cases. Despite substantial improvements in the understanding of the mechanisms that contribute to the origin and responses to sepsis, the prognosis of sepsis-induced cardiac dysfunction (SICD) remains poor and its molecular pathophysiological changes are not well-characterized. The recently discovered group of mediators known as long non-coding RNAs (lncRNAs) have presented novel insights and opportunities to explore the mechanisms and development of SICD and may provide new targets for diagnosis and therapeutic strategies. LncRNAs are RNA transcripts of more than 200 nucleotides with limited or no protein-coding potential. Evidence has rapidly accumulated from numerous studies on how lncRNAs function in associated regulatory circuits during SICD. This review outlines the direct evidence of the effect of lncRNAs on SICD based on clinical trials and animal studies. Furthermore, potential functional lncRNAs in SICD that have been identified in sepsis studies are summarized with a proven biological function in research on other cardiovascular diseases.

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Section: Lncrna Involved In Sicd Among Various Cell Typesmentioning

confidence: 99%

The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction

Zhang

et al. 2021

Front. Cardiovasc. Med.

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Soybean‐derived peptide protects against an E. coli‐induced sepsis in cynomolgus monkeys

Liu

Ren

et al. 2023

Food Frontiers

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Sepsis is a life‐threatening condition that requires urgent medical attention. In this study, we investigated the potential of soybean‐derived peptides (soy peptides) as an anti‐inflammatory supplement for patients with sepsis. Cynomolgus monkeys were induced with sepsis by intravenous administration of three different concentrations of Escherichia coli (6.3 × 103, 6.3 × 105, and 6.3 × 107 CFU/kg). Changes in body weight and inflammatory markers were analyzed, and the high dose of 6.3 × 107 CFU/kg was found to be the most appropriate for sepsis modeling. Controlled enzymatic hydrolysis was then used to release bioactive soy peptides from soy protein isolate, which were administered to monkeys with sepsis. The results showed that soy peptide supplementation significantly suppressed inflammatory responses and improved coagulation abnormalities in the monkeys. Our findings suggest that soy peptides could be an effective clinical nutritional supplement for patients with sepsis, with potential benefits for reducing inflammation and improving coagulation. These results provide a foundation for further research into the development of novel nutritional supplements for patients with sepsis.

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Human Umbilical Cord Blood Mesenchymal Stem Cell Transplantation in Kidney Injury Animal Models: A Critical Review

Perše

Večerić-Haler

2022

Stem Cell Biology and Regenerative Medicine

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Мышиные Модели Сепсиса И Септического Шока

Cited by 22 publications

References 172 publications

The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction

The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction

Soybean‐derived peptide protects against an E. coli‐induced sepsis in cynomolgus monkeys

Human Umbilical Cord Blood Mesenchymal Stem Cell Transplantation in Kidney Injury Animal Models: A Critical Review

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