Определение Объема Кровопотери При Моделировании Травм Паренхиматозных Органов  С Аппликацией Новых Гемостатических Средств В Эксперименте

Майстренко, А Н; университет, Курский государственный медицинский; Бежин, А И; Lipatov, Vilen; Чижиков, Г М

doi:10.21626/innova/2018.2/03

Cited by 3 publications

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“…[12,13,16,17]. Однако и эти материалы не всегда отвечают предъявляемым требованиям, что диктует необходимость разработки более совершенных образцов [18].…”

Section: Introductionunclassified

Application of chitosan-based wound dressings in local treatment of parenchymal organ wounds: a preclinical experimental study

Gumenyuk,

Ushmarov,

Shokel

et al. 2023

Kuban. nauсh. med. vestnik

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Background. Injuries of various origins with damage to parenchymal organs remain one of the urgent issues of emergency surgery, despite all the achievements of medical science of the first quarter of the XXI century. One way to improve the quality of treatment for patients with this pathology consists in developing new wound dressings or modifying the properties of existing ones. Hemostatic efficacy is claimed to be one of the main requirements for such dressings.Objective. To perform a comparative analysis of the efficacy of the developed biodegradable wound dressings based on chitosan in the treatment of experimental wounds of parenchymal organs.Methods. The study involved laboratory animals (male rabbits weighing 2900 ± 150 g) to form experimental wounds of parenchymatous organs. The methodology involved wounding the liver via internal method, with the creation of a tissue defect of a given volume, or forming a linear incised wound with fixed parameters followed by application of a developed wound dressing. In the control group of animals, a collagen hemostatic sponge was used as a wound dressing. The animals used in the experiment were kept in accordance with GOST 33044-2014 “Principles of good laboratory practice”. The experiment involved studying the properties of two samples of wound dressings developed on the basis of modified Chitosan Soft (Ch-S) and Chitosan Hard (Ch-H) chitosan, having different properties due to their different structural parameters. The applied ultrasound control of the experimental wound area, with visualization of the samples of the investigated material in the process of biodegradation, enabled the features of the wound process to be studied in more detail. Statistical processing of the study results was carried out by methods of variational statistics, including the calculation of mean values (M), standard errors of mean values (± m). The criterion of the level of statistical significance considered a value of p <0.05. Histomorphological examination of samples was carried out using classical methods.Results. An experimental study conducted on laboratory animals in the treatment of liver wounds, followed by a comprehensive assessment of the results obtained, revealed high efficacy in the developed wound dressings in comparison with the control. The following parameters predicted in the development of wound dressing samples were confirmed: stable hemostatic and scaffold functions, biodegradability, adhesiveness and stimulating effect on bioreparative processes in the wound area. In addition, the ultrasound control algorithm in vivo was adapted in animals to assess the dynamics of the wound process and biodegradation of the studied wound dressings in wounds of parenchymal organs in the experiment, previously used in studying the dynamics of the wound process in soft tissues.Conclusion. The developed samples of chitosan-based wound dressings proved their efficacy in an experimental model of the wound process in parenchymal organs. The applied ultrasonic method for monitoring the biodegradation of the studied wound dressing, as well as the dynamics of the wound process in the liver tissue, revealed the correspondence between the visualized image and the histomorphological picture of the studied tissues, the structure and properties of the wound dressing.

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Section: Introductionunclassified

Application of chitosan-based wound dressings in local treatment of parenchymal organ wounds: a preclinical experimental study

Gumenyuk,

Ushmarov,

Shokel

et al. 2023

Kuban. nauсh. med. vestnik

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Combined Blunt Splenic Injury in Adults: Modern Approach to Diagnosis and Treatment

Александров

Maskin

Матюхин

2021

Neotložnaâ med. pomoŝʹ

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Background. The high frequency of injuries of the spleen, as well as its important immunocompetent role in the body, dictate the need to develop a standardized approach to the diagnosis and treatment of this category of patients.Aim. Standardization of the treatment and diagnostic approach for combined blunt splenic injury to improve treatment results.Material and methods. The analysis of literary sources of Russian and foreign authors on this issue.Results. The therapeutic and diagnostic algorithm was developed for combined blunt splenic injury based on the severity of the patient, and a detailed description of non-operative and damage control surgical treatment was given.Conclusion. The use of endovascular interventions in the treatment of splenic injuries, as well as their gradual treatment in conditions of severe polytrauma, helps to reduce mortality.

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Prospects of the Use of Chitosan-Based Wound Dressing for the Treatment of Liver Wounds

Gumenyuk,

Ushmarov,

Gumenyuk

et al. 2024

Themed Collection of Papers From II Foreign International Scientific Conference «Science in the Era of Challenges and Global Ch

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The research of hemostatic and wound healing ability of two types of chitosan-based wound dressing under conditions of liver injury has been carried out in vivo. Acceleration of the time of final hemostasis, reduction of blood loss volume and probability of posthemorrhagic complications, as well as improvement of repair of damaged areas of liver parenchyma with biodegradation of the coating itself within a given period of time have been experimentally proved.

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Определение Объема Кровопотери При Моделировании Травм Паренхиматозных Органов С Аппликацией Новых Гемостатических Средств В Эксперименте

Cited by 3 publications

References 0 publications

Application of chitosan-based wound dressings in local treatment of parenchymal organ wounds: a preclinical experimental study

Application of chitosan-based wound dressings in local treatment of parenchymal organ wounds: a preclinical experimental study

Combined Blunt Splenic Injury in Adults: Modern Approach to Diagnosis and Treatment

Prospects of the Use of Chitosan-Based Wound Dressing for the Treatment of Liver Wounds

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