The article aims to analyze the geopolitical, conflict-related, and strategic interests of Ukraine realized within the framework of the South vector of the state geopolitics through rational and pragmatic cooperation with the trans-regional leader of the region – Turkey. The study aims to identify priority areas of cooperation between Ukraine and Turkey in the Black Sea region for the effective implementation of geostrategic interests of Ukraine and the regularity of development of political defense systems during crises and modern military-political conflicts. The interdisciplinary approach and methods of analytical and comparative analysis made it possible to study and examine the evolution of the value-ideological loads which dominate the implementation of Eastern or Western geopolitical vectors. The necessity to consider political, social, and conflict-related imbalances and integration constraints revealed the pragmatic direction of equidistant foreign policy implementation in a three-dimensional format. This format involves an alternative vector of bilateral cooperation with Turkey and a joint position, which will ensure accelerated development of Ukraine and help avoid pressure from the European Union and the Russian Federation. The defensive type of geostrategy serves as a common denominator in cooperation between countries, providing more substantial interaction at the level of experience exchange on military operations, military-political conflicts in Syria and the Eastern regions of Ukraine, solving problems with separatist regions, implementing programs for refugees and internally displaced persons, developing a parity promotion of integration of Turkey and Ukraine into the EU.