This article examines the concepts of stress resistance, intolerance to uncertainty, anxiety and depressive manifestations. The available data on their interrelationships and the studies on the specifics of military youth stress resistance i were reviewed. High stress resistance becomes critical in conditions of war and military conflicts. It includes adaptability to stressful situations and protecting the psyche from destruction, as well as maintaining a normal physical condition. Our task was to investigate the peculiarities of Ukrainian youth's stress resistance in a current special period for the country. The necessity to do this arose because of the need for psychological support of the population during the war period. Military personnel of the State Border Guard Service of Ukraine, as well as civilian youth having different jobs took part in the survey. The performed empirical study showed peculiarities of correlations of stress resistance with intolerance of uncertainty, anxiety and depressive states. Based on the obtained data, a regression model was calculated and substantiated, which was quite successful and could be useful for predicting and developing stress resistance of young people. The article also presents the recommendations, developed taking into account the results, for practical psychologists on working with youth during the war. They stress the importance of maintaining a healthy lifestyle, nutrition, sleep patterns, balancing work and free time, planning quality rest and propose breathing techniques, tapping techniques, search for a client's resources and personal developmental trainings.