The article discusses the development of a disease of cultivated plants, which was previously not typical for the conditions of Uzbekistan — late blight of potato. On the territory of the Tashkent region and the small educational economy of the Tashkent State Agrarian University in 2015–2020, the presence of late blight was noted on potato crops. The degree of development of the disease is 27.9–36.3%. A study was carried out on the use of new drugs: Antracol 70% and Banjo Forte. The best result in suppressing the disease was shown by the preparation Antracol 70% in the norm of application — 2.0 kg/ha, where 20 days after treatment the biological efficiency was 85.6%. The biological efficacy of Banjo Forte at a rate of 1.0 l/ha was 81.8% on the leaves, 84.1% on the shoots, and 1.5% and 1.0%, respectively, with the development of the disease.