Оценка реакции мозга мышей на воздействие наносекундных микроволновых импульсов по экспрессии белка c-fos, "Радиационная биология. Радиоэкология"

On 17 cultures of stem cells (SK) isolated from the femur of laboratory rats «Wistar», the change in the rate of cell proliferation in vitro after irradiation with 4000 nanosecond microwave pulses with a pPFD of 140 and 1500 W/cm2 at pulse repetition rates of 8 and 13 Hz was experimentally studied. It has been established that exposure to nanosecond RPMR with both intensities affects the rate of proliferation SK. After exposure to 4000 RPMR pulses with 140 and 1500 W/cm2 pPFD and a pulse repetition rate of 8 Hz, inhibition of cell proliferation was observed relative to the control group. After exposure to a pulse repetition rate of 13 Hz at the same intensities, stimulation of proliferation took place, as a result of which the number of stem cells in the studied cultures increased. The main revealed pattern is the dependence of the effect (on the pulse repetition rate and, in part, on the intensity). Understanding the patterns will allow choosing and using the most optimal mode of exposure to achieve the desired result, and knowledge of the primary mechanism will make it possible to enhance or weaken the effect, in particular, the combined effect of RPMR with other factors.

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Stimulation of Mesenchymal Stem Cells Proliferation from the Femur of Wistar Rats by Nanosecond Microwave Radiation: Dependence on the Number of Pulses

Gostyuhina,

Bolshakov,

Samoylova

et al. 2023

Radiation biology. Radioecology

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The effect of nanosecond repetitively pulsed microwave radiation (RPM, 50–4000 pulses, pulse repetition rate of 13 Hz, peak power flux density of 140 W/cm2, carrier frequency of 10 GHz) on the stimulation of me-senchymal stem cells (MSC) proliferation was studied. The effect of exposure was assessed by the change in the number of cells in the culture after a single irradiation with a different number of pulses. The most pronounced effect exerted by the impact with 100 and 50 pulses, and the effect is realized with a maximum speed after 24 hours.

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Оценка реакции мозга мышей на воздействие наносекундных микроволновых импульсов по экспрессии белка c-fos, "Радиационная биология. Радиоэкология"

Cited by 3 publications

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Stimulation of the Proliferation of Mesenchymal Stem Cells from the Femur of Wistar Rats by Nanosecond Microwave Radiation: Dependence on the Number of Pulses

Stimulation of the Proliferation of Mesenchymal Stem Cells from the Femur of Wistar Rats by Nanosecond Microwave Radiation: Dependence on the Number of Pulses

Nanosecond Microwave Pulses Affect Stem Cell Proliferation Rate

Stimulation of Mesenchymal Stem Cells Proliferation from the Femur of Wistar Rats by Nanosecond Microwave Radiation: Dependence on the Number of Pulses

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