The paper presents the results of calculations based on inter-sectoral interregional tools to assess the impact of rail transport in the Siberian regions in the implementation of the Eastern development strategy. With the increasing connectivity of the districts, this policy has an impact on both neighboring and remote areas from the Far East. In General, the calculations show a comprehensive assessment of large-scale economic policy options while ensuring systemic conditions. The instrumental base allows to give quantitative values of consequences of change of options of economic policy with indication of branches and areas and on time period dynamics.