Половые Различия В Тревожно-Депрессивном И Оборонительном Поведении Крыс Вистар

Павлова, И. В.; Брошевицкая, Н. Д.; Онуфриев, М. В.; Моисеева, Ю. В.

doi:10.31857/s0044467720020100

Cited by 3 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present work, we did not use the reflex extinction paradigm. The data obtained 24 h after the acquisition showed no sex differences, which is consistent with the data reported by Pavlova et al [46]. Summing up these findings and data obtained in our study, we suppose that in Wistar rats learning and memory in the PA paradigm are neither sex nor age dependent.…”

Section: Passive Avoidancesupporting

confidence: 93%

“…Of note, Pavlova et al [46] recently reported no sex differences in the transfer latency, but they revealed the following differences between naïve four-month-old male and female Wistar rats:…”

Section: Passive Avoidancementioning

confidence: 95%

“…In addition, on each Retention trial, we counted the number of peeps when the animal put its head into the dark compartment and the number of incomplete transfers when the rat entered the dark compartment with 1-3 paws. We also assessed the quality of the conditioned PA reflex by the method described by Pavlova et al [46], using a point system: 5, the rat does not enter and does not peep into the dark compartment; 4, the rat does not enter, but peeps into the dark compartment; 3, the rat does not enter, but peeps into and makes an incomplete transfer; 2, the rat enters the dark compartment with a higher latency than in the control experiments; and 1, the rat enters the dark compartment with latency not higher than in the control experiments.…”

Section: Passive Avoidance Paradigmmentioning

confidence: 99%

“…Recent studies with Wistar rats in cOF under bright light (350 lx) have revealed age-related differences in locomotor activity between naïve male and female rats: After 3 months, males decreased their locomotor activity, while females increased it, which led to sex differences in this index [46]. In our study, the locomotor activity of both female and male rats in the cOF decreased with age even under brighter light (approximately 500 lx), but the locomotor activity remained higher in females throughout the experiment (Figure 5).…”

Section: Open Fieldmentioning

confidence: 99%

“…Along with the quantitative assessment of the PA reflex, we also applied the qualitative assessment proposed by Pavlova et al [46]. The analysis revealed sex differences, but only between single-housed animals.…”

Section: Passive Avoidancementioning

confidence: 99%

See 4 more Smart Citations

Prolonged Social Isolation, Started Early in Life, Impairs Cognitive Abilities in Rats Depending on Sex

2020

View full text Add to dashboard Cite

Background: The chronic stress of social isolation is a valid predictor of cognitive pathology. This study aimed to compare the effects of long-term social isolation on female versus male Wistar rats’ learning and memory. We hypothesized that prolonged social isolation stress, which starts early in life, would affect learning in a sex-dependent manner. Methods: Social isolation started at the edge of early to mid-adolescence and lasted 9 months. The rat’s cognitive abilities were assessed by habituation and reactivity to novelty in the open field (OF) test, spatial memory in the Morris water maze (MWM), and the conditioned passive avoidance (PA) reflex. Basal serum corticosterone levels were assessed using an enzyme-linked immunosorbent assay. Results: Regardless of the housing conditions, females habituated to the OF under low illumination slower than males. Under bright light, the single-housed rats showed hyporeactivity to novelty. In the MWM, all the rats learned to locate the platform; however, on the first training day, the single-housed females’ speed was lower relative to other groups. Four months later, in the post-reminder probe trial, the single-housed rats reached the area around the platform site later, and only males, regardless of housing conditions, preferred the target quadrant. Single-housed rats, irrespective of sex, showed a PA deficit. There was a more pronounced conditioned fear in the single-housed males than in females. In both male and female rats, basal corticosterone levels in rat blood serum after 9 months of social isolation did not differ from that in the group-housed rats of the corresponding sex. Meanwhile, females’ basal corticosterone level was higher than in males, regardless of the housing conditions. The relative weight of the adrenal glands was increased only in single-housed females. Conclusions: Under long-term social isolation, started early in life, single-housed females compared with males showed more pronounced cognitive impairments in the MWM and PA paradigm, findings that specify their greater vulnerability to the stress of prolonged social isolation.

show abstract

Section: Passive Avoidancesupporting

confidence: 93%

Section: Passive Avoidancementioning

confidence: 95%

Section: Passive Avoidance Paradigmmentioning

confidence: 99%

Section: Open Fieldmentioning

confidence: 99%

Section: Passive Avoidancementioning

confidence: 99%

See 3 more Smart Citations

Prolonged Social Isolation, Started Early in Life, Impairs Cognitive Abilities in Rats Depending on Sex

2020

View full text Add to dashboard Cite

show abstract

Impaired Cognitive Functions in Prolonged Social Isolation: Results of Human Studies and Animal Experiments

Krupina,

Shirenova

2024

Neurosci Behav Physi

View full text Add to dashboard Cite

Cognitive Impairment under Prolonged Social Isolation: Insights from Human Studies and Animal Experiments

Krupina,

Shirenova

2023

Uspehi fiziologičeskih nauk

View full text Add to dashboard Cite

Abstract—Having close social connections is essential for mental and physical health and overall well-being, regardless of age. A considerable portion of the world’s population has experienced lockdown due to the COVID-19 pandemic. An increasing amount of scientific literature is emerging, focusing on the negative impact of social isolation on attention, memory, perception, executive functions, and other aspects of cognitive processes. These effects can significantly complicate people’s daily lives and diminish their quality of life. In this review, we aim to organize the existing scientific findings on the relationship between social isolation and the development of cognitive impairments in individuals, as observed in longitudinal population studies. Additionally, we analyze data from experimental research on animals to examine how different durations of social isolation impact learning and memory processes. We briefly address the potential links between these social isolation-induced impairments and alterations in the functioning of the hypothalamic-pituitary-adrenal (HPA) axis, one of the stress-reactivity systems, and the immune-inflammatory response.

show abstract

Половые Различия В Тревожно-Депрессивном И Оборонительном Поведении Крыс Вистар

Cited by 3 publications

References 0 publications

Prolonged Social Isolation, Started Early in Life, Impairs Cognitive Abilities in Rats Depending on Sex

Prolonged Social Isolation, Started Early in Life, Impairs Cognitive Abilities in Rats Depending on Sex

Impaired Cognitive Functions in Prolonged Social Isolation: Results of Human Studies and Animal Experiments

Cognitive Impairment under Prolonged Social Isolation: Insights from Human Studies and Animal Experiments

Contact Info

Product

Resources

About