Практические Рекомендации По Лекарственному Лечению Опухолей Вилочковой Железы (Тимомы И Рака Тимуса)

Барболина, Т. Д.; Бычков, М Б; Аллахвердиев, А. К.; Borisova, T. N.; Владимирова, Л. Ю.; Герасимов, С. С.; Dengina, Natalia; Козлов, Н. А.; Лактионов, К. К.; Левченко, Е. В.; Малютина, Д. В.; Пикин, О. В.

doi:10.18027/2224-5057-2020-10-3s2-35

Cited by 2 publications

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“…Further numerous works of foreign and Ukrainian authors considerably expanded the understanding of the origin of this syndrome; however, surgical treatment methods were not used until the middle or end of the previous century. The first mentions of successful azygo-atrial anastomosis for SVCS date back to 1951 [10,11]. In the same year, Sampsen combined the azygos vein with the right atrium using venous autotransplant.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of surgical reconstruction of the superior vena cava syndrome in patients with locally advanced thymomas

et al. 2021

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The aim of the study: to study and demonstrate the potential and technical aspects of the surgical treatment of locally advanced thymus tumours with the tumour infiltrate affecting superior vena cava and its branches. Methods. 56 patients with locally advanced thymomas complicated by SVCS were study. The control group included 30 patients with SVCS were treated with conventional techniques, while the experimental group included 26 patients who underwent a novel bypass surgery developed by us. Results. Based on our observations, patients tolerated these surgeries much better. The venous bypass was mandatorily complemented with cytoreduction. Auriculo-jugular (left and right) and auriculo-subclavian (left and right) bypasses were used in our observations Complications in the post-operative period were reported from the experimental group and included auriculo-subclavian bypass thrombosis, post-operative complications were reported in the control group including haemorrhage from the sternotomy wound in 1 (3.3 %) case, superior vena cava thrombosis in 2 (6.6 %) cases, pneumonia in 2 (6.6 %) cases and thromboembolism of small pulmonary arteries in 2 (6.6 %) cases. Post-operative lethality in the study groups was reported in the control and in the experimental group. Total lethality rate was 8.9 % (5 patients). The relative risk of complications and lethal outcome was calculated for patients from both groups. It was found that the risk of complications was twice as high in the control group as in the experimental group (standard error of relative risk equals 0.64), whereas the risk of lethal outcome increased by a factor of 3.5 in the control group (standard error of relative risk equals 1.09) Conclusion. It has been established that the superior vena cava syndrome in patients with locally advanced thymoma is an emergency condition whose surgical correction must be personalised depending on the anatomic and topographic classification of SVC lesion types. It is known that an obligatory pre-condition of the perioperative period in this category of patients is an adequate vascular approach to the superior vena cava system. The first mandatory step of the radical surgery in patients with locally advanced thymomas with SVC invasion should be the auriculo-jugular and auriculo-subclavian bypasses, which can reduce the relative risk of post-operative complications by a factor of the risk of lethal by a factor of 3.5.

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Section: Introductionmentioning

confidence: 99%

Outcomes of surgical reconstruction of the superior vena cava syndrome in patients with locally advanced thymomas

et al. 2021

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The surgical treatment of locally advanced angiosarcoma of the anterior mediastinum. A clinical case

Novikov

Chekini²,

Avturkhanov³

et al. 2022

J. Mod. Onco.

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Tumors of the mediastinum is a collective term that includes neoplasms of various degrees of malignancy, different morphogenesis, originating from heterogeneous tissues and combined into one nosological form according to anatomical localization. Angiosarcoma is a rare malignant tumor originating from a vessel wall. In the general structure of sarcomas, its frequency is estimated at 1%. The tumor is characterized by an aggressive course, local recurrence, hematogenous metastasis, poor sensitivity to chemotherapy and radiotherapy. Surgery remains the main treatment for angiosarcomas. The article presents a clinical case. A 55-year-old patient has multiple primary malignant neoplasms: cancer of the body of the uterus pT1aN0M0 IA stage. Surgical treatment from 12.15.2020 panhysterectomy; angiosarcoma of the anterior mediastinum with lesions of the manubrium, body of the sternum and the 1st rib on the left, invasion into the left brachiocephalic vein with the formation of a tumor thrombus in it, growing into the upper lobe of the left lung, T3N0M0, G1. Surgical treatment from 08.12.2021 resection of the manubrium and body of the sternum with resection of the anterior segments I, II, III ribs on both sides, resection of the left brachiocephalic vein, removal of an anterior mediastinal tumor, atypical resection of the upper lobe of the left lung en bloc, reconstruction of the sternum and ribs with an individual titanium 3D prosthesis. The patient was discharged from the hospital in a satisfactory condition.

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Практические Рекомендации По Лекарственному Лечению Опухолей Вилочковой Железы (Тимомы И Рака Тимуса)

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Cited by 2 publications

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Outcomes of surgical reconstruction of the superior vena cava syndrome in patients with locally advanced thymomas

Outcomes of surgical reconstruction of the superior vena cava syndrome in patients with locally advanced thymomas

The surgical treatment of locally advanced angiosarcoma of the anterior mediastinum. A clinical case

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