Практические Рекомендации По Лечению И Профилактике Мукозитов

Семиглазова, Т. Ю.; Беляк, Н. П.; Владимирова, Л. Ю.; Корниецкая, А. Л.; Королева, И. А.; Нечаева, М. Н.; Раджабова, З. А.; Телетаева, Г. М.; Ткаченко, Е. В.

doi:10.18027/2224-5057-2021-11-3s2-51

Cited by 6 publications

(14 citation statements)

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“…Кроме эффективной противоопухолевой активности 5-фторурацил обладает множеством побоч-ных действий, которым подвержены система кроветворения, печень, кожа, нервные клетки, сердечно-сосудистая и мочевыделительная системы. Но чаще всего страдает слизистая оболочка желудка и кишечника [12][13][14]. При применении 5-фторурацила частота развития данных нежелательных явлений со стороны желудочно-кишечного тракта составляет около 30-40 % [12].…”

Section: результаты и обсуждениеunclassified

“…Но чаще всего страдает слизистая оболочка желудка и кишечника [12][13][14]. При применении 5-фторурацила частота развития данных нежелательных явлений со стороны желудочно-кишечного тракта составляет около 30-40 % [12].…”

Section: результаты и обсуждениеunclassified

“…Воспаление слизистой оболочки желудка и двенадцатиперстной кишки, возникающее вследствие проведения химиотерапии, называется мукозитом [12,14,15]. В патогенезе его возникновения и развития выделяют несколько фаз.…”

Section: результаты и обсуждениеunclassified

“…Но есть некоторые сведения по их лечению. К ним относятся: адекватная гидратация, прием пищи в жидком и полужидком виде (при необходимости установка желудочного зонда), антибиотикотерапия при возникновении инфекции, вызванной патогенной флорой [12].…”

Section: результаты и обсуждениеunclassified

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Erosive-ulcerative lesions of the mucous membrane of the stomach and duodenum during therapy with 5-fluorouracil

Yakimenko

Kutukov

Antonyan

et al. 2022

jour

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Introduction. Adjuvant therapy with the inclusion of 5-fluorouracil is used in patients with neoplasms of the colon and rectosigmoid in the postoperative period. However, along with a positive antitumor effect, 5-fluorouracilcontaining regimens have a negative effect on the mucosa of the gastrointestinal tract, which often leads to the need to replace or cancel drugs, thereby reducing the effectiveness of treatment.Aim of the study was to improve the idea of the possibility of erosive and ulcerative lesions of the stomach and duodenum during treatment with 5-fluorouracil in patients with malignant tumors of the colon and rectosigmoid and the factors that aggravate their course, as well as to highlight the problem of prevention and treatment of gastrointestinal complications.Materials and methods The search for publications by keywords was carried out in the databases of PubMed, Google Scholar, elibrary.ru and Russian specialized journals related to therapy, surgery, gastroenterology, oncology for the period from 2010 to 2022.Results and Discussion An analysis of the literature allows us to conclude that the risk of damage to the mucous membrane of the stomach and duodenum during the use of chemotherapy with the inclusion of 5-fluorouracil is very high and amounts to 30–40 %. In addition, there are many factors that can complicate the course of this undesirable phenomenon. These include the advanced age of patients, the presence of serious comorbidity and postoperative complications in patients, as well as infection with Helicobacter pylori. The lack of generally accepted recommendations for the prevention and treatment of damage to the lining of the stomach and duodenum during the use of chemotherapy is a serious problem in modern medical practice.Conclusion Gastrointestinal toxicity associated with the use of 5-fluorouracil in the form of mucositis in patients with malignant neoplasms of the colon and rectosigmoid deserves close attention. The presence of damage to the mucous membrane of the stomach and duodenum in a patient requires immediate therapy, as this will improve the long-term results of the treatment of the underlying disease and ensure a high quality of life for the patient.

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Section: результаты и обсуждениеunclassified

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Erosive-ulcerative lesions of the mucous membrane of the stomach and duodenum during therapy with 5-fluorouracil

Yakimenko

Kutukov

Antonyan

et al. 2022

jour

View full text Add to dashboard Cite

show abstract

“…Кроме эффективной противоопухолевой активности 5-фторурацил обладает множеством побочных действий, которым подвержены система кроветворения, печень, кожа, нервные клетки, сердечно-сосудистая и мочевыделительная системы. Но чаще всего страдает слизистая оболочка желудка и кишечника [12,13,14]. При применении 5-фторурацила частота развития данных нежелательных явлений со стороны желудочно-кишечного тракта составляет около 30-40% [12].…”

unclassified

Профилактика Гастроинтестинальных Нежелательных Явлений Во Время Терапии 5-Фторурацилом

Кутуков¹,

Антонян²,

Якименко³

et al. 2022

Профилактика Гастроинтестинальных Нежелательных Явлений Во Время Терапии 5-Фторурацилом

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Gastrointestinal toxicity arising from the use of 5-fluorouracil in the form of mucositis in patients with malignant neoplasms of the colon and rectosigmoid deserves close attention. An analysis of the literature allows us to conclude that the risk of damage to the mucous membrane of the stomach and duodenum during the use of chemotherapy with the inclusion of 5-fluorouracil is very high and amounts to 30-40%. In addition, there are many factors that can complicate the course of this undesirable phenomenon. These include the advanced age of patients, the presence of serious comorbidity and postoperative complications in patients, as well as infection with Helicobacter pylori. The lack of generally accepted recommendations for the prevention and treatment of damage to the lining of the stomach and duodenum during the use of chemotherapy is a serious problem in modern medical practice.

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Personalized or unified approach in the prevention and treatment of oral mucositis in patients with malignant neoplasms of the head and neck organs: the choice of the optimal solution

Gvozdikova

Аванесов

Khalil

et al. 2022

Opuholi golovy i šei

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Introduction. The prevalence of oncological diseases of the oropharyngeal region continues to grow steadily, but there is an increase for a number of nosologies in the five-year survival rate of this category of patients, which naturally leads to the actualization of accompanying treatment programs and the desire to improve the quality of life of oncological patients. One of the areas of maintenance therapy in oncology is dental support, the choice of approaches and methods of which is not systematically organized.Aim. To determine the optimal method of dental support for patients with malignant neoplasms of the head and neck organs for the prevention and treatment of oral mucositis.Materials and methods. At the Russian Scientific Center of Roentgenoradiology, retrospective analysis of scientific clinical results of oral mycosis treatment in patients with malignant tumors of the head and neck receiving antitumor therapy was performed.Results. Two main approaches have been identified for the prevention and treatment of oral mucositis in patients with malignant neoplasms of the head and neck organs: personalized and unified approach. using personalized approach, maximal mean value of oral mycosis severity during the whole antitumor treatment period per the Radiation therapy Oncology group (RTOg) classification was 2.19 ± 0.13. The quality of life of patients is reduced by 26.1 %. using unified approach, maximal mean value of oral mycosis severity during the whole antitumor treatment period per the RTOg classification was 2.44 ± 0.05. The quality of life of patients is reduced by 51.5 %, but at the same time, absolutely all patients retain the ability to eat independently and take care of the oral cavity.Conclusion. Both personalized and unified approaches for the prevention and treatment of oral mucositis are possible for use in clinical practice.

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Практические Рекомендации По Лечению И Профилактике Мукозитов

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Cited by 6 publications

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Erosive-ulcerative lesions of the mucous membrane of the stomach and duodenum during therapy with 5-fluorouracil

Erosive-ulcerative lesions of the mucous membrane of the stomach and duodenum during therapy with 5-fluorouracil

Профилактика Гастроинтестинальных Нежелательных Явлений Во Время Терапии 5-Фторурацилом

Personalized or unified approach in the prevention and treatment of oral mucositis in patients with malignant neoplasms of the head and neck organs: the choice of the optimal solution

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