The results of recent study of the Earth’s crust based on the gravity data of the GOCE satellite were used for a comparative metallogenic analysis of the geodynamic settings of polymetallic deposits in the folded frame of Siberian and East European platforms. It is shown that deposits of the SEDEX type are more often located in the earth’s crust with the predominant development of the lower “basalt” layer. Pyrite copper and lead-zinc deposits (VMS), as well as some occurrences of the SEDEX type, are known in subduction island-arc and accretionary settings on the crust with the predominant development of the middle “granite” layer. Pb–Zn ores of the MVT-type are localized in deep pericratonic sedimentary oilgas basins on the shelf and continental slope, with no spatial relationship with the stratification of the earth’s crust. The Ag-polymetallic mineralization of Taimyr and Western Verkhoyansk are confined to deep pericratonic rift troughs on the passive continental margin, have a similar ore-bearing environment and may be considered as a single silver-polymetallic Taimyr-West Verkhoyansk belt. The obtained results to confirm the prospects of Pb–Zn deposits in Central and Eastern Taimyr, as well as the Saurey ore region (Polar Urals) and the need for their further research.