Раціональний Вибір Монотерапії Для Лікування Цд 2 Типу На Основі Фармакоекономічного Аналізу

Germanyuk, Т. А.; Івко, Т. І.

doi:10.15587/2313-8416.2014.32109

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Almost 104,000 Ukrainians have been diagnosed with diabetes for the first time in 2017 -2% more than in 2016. [1,2] During from ten to fifteen years, diabetes can be cause a great deal of damage to the whole body, especially if there are significant complications, even if all the requirements for treatment and diet are met. Most often, with this disease, the composition of the blood changes, which leads to chronic damage to all vital organs.…”

Section: Introductionmentioning

confidence: 99%

The Study of Action the Ozone in the Surgical Treatment of Inflammatory Processes by Diabetes Mellitus

et al. 2021

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The aim: was to improve the course of purulent wounds in diabetes by using physical therapies. Materials and methods: we investigated 122 patients with diabetes mellitus and wound processes. We divided all patients on the two groups. Our study groups were 50 patients who had therapy by ozone together with other general treatment and surgery treatment (daily dressings, ointments and solutions). Our control groups were 72 patients, who had treated only by general methods and surgery treatment (daily dressings, ointments and solutions).The patients of our explore group had received intravenous injection of saline ozone solution together with other general treatment and surgery treatment (daily dressings, ointments and solutions). Results: it had studied of indicators of oxidative modification of proteins, lipid peroxidation in blood plasma, antioxidant protection during this period, there were no significant changes in these parameters between the control and experimental groups. As the result of the study was found that the leukocyte index of intoxication in patients in the main and control groups was almost indistinguishable. Regarding the indexes of hematological index of intoxication, which decreased during the treatment of patients of the main group, and different from the patients of the control group, in which this indicator increased sharply. The result of the study of changes in the indicators of sorption capacity of erythrocytes showed that the level of sorption capacity of erythrocytes in patients in the main group during treatment, also decreased, compared with patients in the control group. Conclusions: Therefore, the use of ozone in the treatment of patients with complicated forms of diabetes does not cause a negative impact on the dynamics of homeostasis and indicators of the level of intoxication of the body. Ozone therapy has a beneficial effect on the course and wound process in patients with diabetes with purulent processes.

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Section: Introductionmentioning

confidence: 99%

The Study of Action the Ozone in the Surgical Treatment of Inflammatory Processes by Diabetes Mellitus

et al. 2021

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Development of HPLC-MS Method of Voglibose and Quercetin Quantitation in Hypoglicemic Action Tablets

Kovalevska

Рубан

Khanin³

2019

EUREKA: Health Sciences

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Aim. The purpose of our study was to develop a method for simultaneous quantitation of voglibose and quercetin in a solid dosage form. Materials and methods. The objects of the study were voglibose, quercetin, tablets containing voglibose - 0.2 mg and quercetin 100 mg. Measurements were carried out by high-performance liquid chromatography (HPLC) according to SPHU, supp. 1, 2.2.29, N, using the following equipment: a mass-selective detector Agilent 6530 Q-TOF was used as the detecting system. Results. According to the developed method, the quantitative determination of voglibose and quercetin in the tablets of hypoglycaemic action was investigated. The following results were obtained: the content of C 10 H 21 NO 7 (voglibose) in one dosage unit of the test drug was 0.2 mg; and the content of C 15 H 10 O 7 (quercetin) -0.105 g, which suggests the validability of the proposed method for quantitation of the active substances in tablets for the prevention and treatment of type II diabetes mellitus. Conclusions. In the course of the study, a method was developed for determination of voglibose and quercetin in a hypoglycaemic action preparation using high-performance liquid chromatography (HPLC) with a gradient mode of elution. It has been established that the chosen chromatographic conditions allow quantitative determination of the active pharmaceutical ingredients studied in a solid dosage form with a tolerance of ±5 %. Validation of the developed methodology has been conducted and its suitability for the simultaneous quantification of quercetin and voglibose in tablets has been demonstrated. The reproducibility of this method has been proved.

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Раціональний Вибір Монотерапії Для Лікування Цд 2 Типу На Основі Фармакоекономічного Аналізу

Cited by 2 publications

References 3 publications

The Study of Action the Ozone in the Surgical Treatment of Inflammatory Processes by Diabetes Mellitus

The Study of Action the Ozone in the Surgical Treatment of Inflammatory Processes by Diabetes Mellitus

Development of HPLC-MS Method of Voglibose and Quercetin Quantitation in Hypoglicemic Action Tablets

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