Сorrective influence of Нentabiferon-Сon the immune status of post-weaned piglets and its effectiveness in the prevention of intestinal infections

Востроилова, Г. А.; Shakhov, A. G.; Shabunin, S. V.; Sashnina, L. Yu.; Parshin, P. A.; Cheskidova, L. V.; Kantorovich, Yu. A.

doi:10.31857/s250026270001834-2

Cited by 2 publications

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“…The treatment may include antimicrobial therapy and stimulation of the natural resistance of the animal's body. Therefore, to increase the effectiveness of chemotherapy, it is advisable to use complex drugs with antimicrobial and immunomodulatory activity (2).…”

Section: Introductionmentioning

confidence: 99%

Study of Mutagenic and Antitoxic Properties of Gentabiferon-B

Shabunin

Gritsyuk

Востроилова

et al. 2022

Macedonian Veterinary Review

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The combination of immunomodulators and antibiotics in the treatment of animals with diseases of bacterial etiology is one of the effective strategies for animal therapy. The drug gentabiferon-B combines antibiotic gentamicin and species-specific (bovine) recombinant interferons -α and -γ. The study aimed to evaluate the effect of course application of gentabiferon-B on the cytogenetic stability of bone marrow cells of outbred mice after administering mitomycin C (MMC). The proportion of polychromatophilic erythrocytes in the bone marrow was assessed. There was no effect of gentabiferon-B on the frequency of polychromatophilic erythrocytes with micronuclei in both healthy animals and mice with MMC-induced cytogenetic instability. The course application of gentabiferon-B before the administration of MMC led to an increase in the proportion of polychromatophilic erythrocytes (46.03±2.61%) which was non-significantly different than the negative control group. The administration of MMC alone caused a decrease in the proportion of polychromatophilic erythrocytes to 33.33±1.83%. The antitoxic effect of gentabiferon-B led to an increase in the level of polychromatophilic erythrocytes by 38.1% compared to the group that received only MMC. Studies have shown that gentabiferon-B does not have mutagenic activity and anticlastogenic properties, however, it reduces the toxic effect of MMC. In conclusion, it is indicative that gentabiferon-B has antitoxic properties and can be safely used in animal therapy.

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Section: Introductionmentioning

confidence: 99%

Study of Mutagenic and Antitoxic Properties of Gentabiferon-B

Shabunin

Gritsyuk

Востроилова

et al. 2022

Macedonian Veterinary Review

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Interferons-α and -γ in clinical veterinary practice in the prevention and treatment of infectious diseases in cattle and pigs (review)

Shabunin

Востроилова

Grigoryeva

et al. 2022

Аграрная наука Евро-Северо-Востока

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The review article analyzes the existing world experience in the use of interferons IFN-α and -γ as well as drugs based on them in clinical veterinary practice in cattle and pigs. The selection of literary sources was carried out on the basis of their relevance and the depth of the research (search retrospectiveness is 30 years). It has been established that IFNs are widely used in the prevention and treatment of both infectious and non-infectious diseases, which can be divided into 3 groups: viral infections, oncological diseases, bacterial and aseptic diseases. The use of IFNs is due to their antiviral activity and immunoregulatory effect. Thus, IFN-α exhibits antiviral activity and is the first line of nonspecific immune defense, an inducer of IFN-γ synthesis and the main coordinator of the body's successful response to a viral infection. At the same time, IFN-γ provides immunoregulatory, anti-inflammatory and mediated antibacterial action by stimulating the production of macrophages and participating in the differentiation of lymphocytes. Clinical efficacy is expressed in a decrease or cessation of the infectious process, a decrease in leukocytosis and neutrophilia, relief of acidotic syndrome, an increase in the body weight of animals and an improvement in the general clinical condition. Currently, IFN therapy is one of the most promising and constantly expanding areas of immunopharmacology and treatment of common respiratory, gastrointestinal, obstetric-gynecological diseases in farm animals.

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Сorrective influence of Нentabiferon-Сon the immune status of post-weaned piglets and its effectiveness in the prevention of intestinal infections

Cited by 2 publications

References 0 publications

Study of Mutagenic and Antitoxic Properties of Gentabiferon-B

Study of Mutagenic and Antitoxic Properties of Gentabiferon-B

Interferons-α and -γ in clinical veterinary practice in the prevention and treatment of infectious diseases in cattle and pigs (review)

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