Селен И Здоровье Человека

Rakov, О.V.; Muz, V.A.

doi:10.31793/1680-1466.2019.24-2.178

Cited by 2 publications

(1 citation statement)

References 52 publications

(70 reference statements)

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“…Insufficient intake of selenium in the human body (less than 15-30 μg/day) leads to development one of the hypomicroelementosis -hyposelenosis. About 75 different diseases and pain symptoms are associated with selenium scarce (Rayman, 2012;Rakov & Muz', 2019). Selenium scarce is considered as a possible etiological factor of 14 cardiovascular diseases, including distal cardiomyopathy (Keshan's disease), atherosclerosis, coronary heart disease, myocardial infarction, arterial hypertension, etc.…”

Section: Ukrainian Journal Of Ecology 10(4) 2020mentioning

confidence: 99%

Selenium in natural environment and food chains. A Review

Sobolev¹,

Gutyj²,

Соболева³

2020

Ukr J Ecol

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The analytical review attempts to summarize the results of numerous scientific research conducted by scientists around the world on selenium scattering and accumulation in natural environment, with considerable attention paid to the concentration of this trace element in soils, natural waters and plants. It is shown that selenium content in agricultural products is caused by the processes of physico-chemical and biogenic migration of this element in the biogeochemical food chain. According to the modern classification of trace elements, which is based on their biological significance for living organisms, selenium belongs to the vital group or biogenic elements. As a biotic element, it has unique physicochemical and biochemical properties and with adequately absorbed into the human body has a positive effect on a number of physiological processes. Various research shows that the majority of the world population (except in some regions) today consumes less selenium with the food than necessary and its consumption decreases every year. Insufficient selenium intake in the human body (less than 15–30 μg/day) leads to the development one of the hypomicroelementosis – hyposelenosis. Selenium deficiency is considered as a possible etiological factor in some cardiovascular, cancer, osteoarticular and neurodegenerative diseases that threaten to human life. Providing the human body with selenium in optimal amounts is one of the important conditions of nutrition. A number of countries have developed recommended selenium intake standards for the adults, which range from 55 to 120 μg/day. We can calculate the physiological need for selenium in children and adolescents by extrapolation. The most safe and effective way to maintain the necessary level of selenium for the human body can be achieved only through the poultry and livestock products by mandatory introduction of premixes containing highly effective biologically available selenium forms into animal feed. This will ensure a relatively high level of trace element in meat, eggs, and milk and would eliminate the cases of toxicosis in human population due to buffer effect of animal tissues.

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Section: Ukrainian Journal Of Ecology 10(4) 2020mentioning

confidence: 99%

Selenium in natural environment and food chains. A Review

Sobolev¹,

Gutyj²,

Соболева³

2020

Ukr J Ecol

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Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector

Бєленічев¹,

Gorchakov²,

Samura³

et al. 2021

RRP

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Selenium is an essential component of more than two dozen enzymes and other selenoproteins that play critical roles in reproduction, DNA synthesis, thyroid hormone metabolism, and protection from oxidative damage and infection. Selenium has a protective action against some forms of cancer and cardiovascular diseases, modulates levels of inflammatory mediators, promotes to maintain bone homeostasis and protects against bone loss. Selenium significance as a cardioprotective agent may be associated not only with its antioxidant properties, but also with its ability to prevent inflammation, autophagy, as well as the intrinsic and extrinsic apoptosis pathways. Signaling pathways, such as p-AMPK, PARP, Nrf2, STAT, are involved in the protective effects of selenium. Selenium protects against cardiovascular damage by increasing the survival rate of cardiomyocytes, including a mitochondria-dependent pathway and autophagy through peroxisome proliferator-activated receptors. Research demonstrating neuroprotective and cardioprotective effects of selenium preparations – selenoline, selenocysteine and selenomethionine – is growing at a rapid rate. It has been established that these compounds are able to normalize the levels of heat shock proteins (HSP70), which limit the cytotoxic effects of free radicals, produce energotropic action, prevent a decrease in the membrane mitochondria charge, and the opening of the mitochondrial pore. Also regulate the expression of transmembrane factors NF-kB, c-fos, which is associated with their main biological function of chaperone proteins, providing protection of neurons from damage. In this review, we want to emphasize pharmacological role of Selenium and its derivatives on human health is very complex and has yet to be fully understood.

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Селен И Здоровье Человека

Cited by 2 publications

References 52 publications

Selenium in natural environment and food chains. A Review

Selenium in natural environment and food chains. A Review

Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector

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