2024
DOI: 10.21320/2500-2139-2024-17-4-376-383
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Субпопуляционный Состав Лимфоцитов Костного Мозга При Хроническом Лимфоцитарном Лейкозе У Пациентов С Различным Ответом На Противоопухолевое Лечение

Олеся Николаевна Селютина,
Е. Ю. Златник,
Н. К. Гуськова
et al.

Abstract: AIM. To analyze the bone marrow lymphocyte subpopulation based on targeted assessment of PD-1, PD-L1, and LAG-3 marker expression in chronic lymphocytic leukemia (CLL) patients with different responses to chemotherapy. MATERIALS & METHODS. In 33 CLL patients, PD-1, PD-L1, and LAG-3 antigen expression on В-, Т-, and NK-cells of the bone marrow (BM) was analyzed by flow cytofluorometry prior to treatment and after 6 cycles of chemotherapy with rituximab. Patients were aged 58–68 years (median 64 years); the… Show more

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