The dynamics of foreign economic activity in the Republic of Tyva for 2015–2021, the change in the foreign trade turnover of Tuva with Mongolia, with countries of near and far abroad are analyzed. Trade turnover of Tuva with external partners has a positive balance. A significant share of foreign trade turnover falls on non-CIS countries. It is noted that the nature of trade and economic relations with Mongolia is influenced by the relative development of the transport system of Tuva, the republic does not have a railway connection with the rest of the country. New opportunities for further expansion of interregional and strengthening international economic relations between the two neighboring regions are due to the possibilities of solving infrastructure problems, joining the region to the Russian railway network. It is proposed to use new tools for developing foreign economic relations, expanding the space for interregional cooperation, innovative approaches to attracting investments, and strategies for developing the region's foreign economic activity. The creation of a cross-border special economic region and a cross-border corridor Russia — Mongolia — China are substantiated.