The article is devoted to the study of theoretical and applied aspects of decent work during the period of unstable economy development associated with the pandemic. The aim of research is to identify key labor trends, determine valid indicators and analyze decent work profiles at the level of the world community, Russia and its regions. The authors analyzed the decent work profiles at the beginning and during the downturn of the pandemic; studied the components of decent work in the economy as a whole and at the regional level. Special attention is paid to the criteria of profiling, which determine the necessary investment directions and formats in ensuring decent work conditions in the country context. Indicators and an integral indicator of decent work, taking into account the conditions of the pandemic, including unemployment; expenditure in GDP and payments against the subsistence minimum; loss of working time due to restrictive measures; the proportion of workers transferred to remote employment; Wage change rate; occupational safety index and others are proposed. The materials can be of practical value for the employment policy directions development at the regional and Federal levels of Russia, taking into account the current epidemiological situation and employment digitalization strategic priorities.