Участие Мелатонина В Происхождении Патологических Процессов В Костной Ткани И Их Ограничении

Арушанян, Эдуард Бениаминович

doi:10.30906/0869-2092-2015-78-2-39-44

Эксп. и клин. фармакол.

2015

DOI: 10.30906/0869-2092-2015-78-2-39-44

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Участие Мелатонина В Происхождении Патологических Процессов В Костной Ткани И Их Ограничении

Эдуард Бениаминович Арушанян¹

Abstract: Мелатонин, продуцируемый эпифизом и клетками периферических тканей, посредством специфических рецепторов контролирует обмен в костной ткани и участвует в происхождении костной патологии. Современные экспериментальные доказательства его остеогенной активности позволяют рассматривать мелатонин в качестве потенциального лекарственного средства при различных видах заболеваний костей.

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Cited by 2 publications

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Analysis of rat jaw bone tissue elemental composition in a model of periodontitis

Sarkisyan,

Kataeva,

Khokhryakova

et al. 2024

Russian Journal of Immunology

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The elemental composition of jaw bone tissue depends on many external and internal factors affecting the body. The structure of bone tissue directly reflects its ability to restrain inflammation and regenerate after exposure to damaging factors. The purpose of the study is to study the elemental composition of the rat jaw bone tissue during chronic periodontal inflammatory process. A month later, the individual was removed from the experiment by an overdose of ether to isolate the bone segment under study. Next, the bone tissue sample was studied using atomic emission spectroscopy. In the studied segment of bone tissue, 67 chemical elements were identified in a quantitative range of up to 10-4 mass percent. The highest mass fraction belongs to the basic elements of bone tissue: calcium, phosphorus, magnesium, sodium, and sulfur. While during the experiment the animals received standard complete feed, which contained proteins, vitamin D close to normal, Ca, P and Se. In the bone tissue sample under study, the quantitative Ca/P ratio was 1.685, which slightly exceeds the optimal one. An increase in this indicator is associated with a decrease in phosphorus content in bone tissue, which can be explained by insufficient daily intake of this element from food, as well as a number of local factors. When the jaw is traumatized during the modeling of periodontitis, an inflammatory process occurs in this area, the experimental animal experiences stress, which leads to demineralization of the tissues of the alveolar process of the jaw, as evidenced by a decrease in the content of phosphorus and selenium in the bone tissue. In addition, elemental analysis showed the presence of foreign elements in the bone tissue, the amount of which corresponds to the range from 0.001% to 0.06%. Basically, these are elements that form simple substances - metals: bismuth, gallium, lead, iridium, titanium, zinc, mercury, molybdenum. The results of the study can be taken into account when planning and conducting polyetiotropic therapy for inflammatory-dystrophic periodontal diseases in the early stages of their development.

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Analysis of rat jaw bone tissue elemental composition in a model of periodontitis

Sarkisyan,

Kataeva,

Khokhryakova

et al. 2024

Russian Journal of Immunology

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КЕРАМИКА НА ОСНОВЕ ПОРОШКОВЫХ СМЕСЕЙ, СОДЕРЖАЩИХ ГИДРОФОСФАТЫ КАЛЬЦИЯ И СОЛИ НАТРИЯ (NA2CO3, NA4P2O7, NAPO3), "Неорганические Материалы"

Сафронова¹,

Путляев²,

Филиппов³

et al. 2018

Неорганические материалы

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Керамику в системе Na2O-CaO-P2O5 получали из порошковых смесей, включающих гидрофосфаты кальция (монетит/брушит, CaHPO4/CaHPO4.2H2O) и соли натрия (Na2CO3.Н2О, Na4P2O7.10Н2О, NaPO3). Указанные соли были взяты в качестве прекурсоров следующих высокотемпературных фаз: Сa2P2O7, Na2O, Na4P2O7, NaPO3. Количество добавок солей в порошковой смеси было рассчитано таким образом, чтобы оксидный состав керамики соответствовал 10 мол.% оксида натрия для каждой смеси в системе Na2O-CaO-P2O5. Порошковые смеси готовили с использованием механической активации в ацетоне, при проведении которой наблюдали явление регидратации монетита до брушита. По данным РФА, после обжига фазовый состав керамики из подготовленных порошковых смесей принадлежал области Сa2P2O7-NaCaPO4-Na2СaP2O7-Са(РО3)2. Полученные керамические материалы включают биосовместимые резорбируемые фазы и могут быть рекомендованы для изготовления костных имплантатов.

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Участие Мелатонина В Происхождении Патологических Процессов В Костной Ткани И Их Ограничении

Cited by 2 publications

References 39 publications

Analysis of rat jaw bone tissue elemental composition in a model of periodontitis

Analysis of rat jaw bone tissue elemental composition in a model of periodontitis

КЕРАМИКА НА ОСНОВЕ ПОРОШКОВЫХ СМЕСЕЙ, СОДЕРЖАЩИХ ГИДРОФОСФАТЫ КАЛЬЦИЯ И СОЛИ НАТРИЯ (NA2CO3, NA4P2O7, NAPO3), "Неорганические Материалы"

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