Цитомегаловирусная И Смешанные Вирусные Инфекции У Пациентов С Воспалительными Заболеваниями Кишечника

Abstract

Background. The issue of the prevalence of opportunistic infections in persons with inflammatory bowel disease (IBD) remains relevant. Among opportunistic infections, in particular, we would like to note Herpesviridae family (herpes simplex virus type 1 and 2), human herpesvirus type 3 (varicella zoster virus), human herpesvirus type 4 (Epstein-Barr virus), cytomegalovirus (CMV), or human herpesvirus type 5, human herpesvirus type 6 and parvovirus B19. Clinically marked herpes and parvovirus infections are frequent causes of systemic inflammation of the gastrointestinal tract. This is a serious problem, especially for persons with long-term immunosuppression, who have IBD, and special attention in this aspect is paid to cytomegalovirus infection. Clinical activity of CMV-associated IBD, its duration and severity, as well as the use of steroids and anti-TNF-α agents were identified as risk factors for adverse outcomes. It is important not only to detect the presence of viruses in the patient's body, but also to clarify their etiological role in the development of the disease. According to the current European Crohn's and Colitis Organisation (ECCO) protocols, all patients with IBD are recommended to be screened in hormone resistance, loss of effect from maintenance therapy and severe attacks of the disease. The addition of active CMV infection to IBD may likely be one of the causes of resistance to hormone and immunosuppressive therapy, as well as biological drugs, but this issue requires further researches. The purpose was to evaluate the frequency of detecting isolated cytomegalovirus infection and mixed (herpes and parvovirus B19) viral infections in patients with IBD and their influence on the disease activity. Materials and methods. One hundred and eightynine patients (98 women and 91 men) with IBD (102 with ulcerative colitis (UC) and 87 with Crohn's disease (CD)) were examined. The age of patients was from 16 to 63 years (mean age (41.4 ± 4.8) years). In addition to standard clinical endoscopic examinations according to ECCO guidelines, disease activity was assessed by indicators of highly sensitive C-reactive protein, homocysteine, vitamin D in blood serum, albumin in urine, calprotectin and lactoferrin in feces. All patients underwent serological blood test by enzyme-linked immunosorbent assay for specific antibodies to herpesviruses and IgG/IgM antibodies to parvovirus B19, determination of DNA of herpes simplex viruses types 1, 2, 6, Epstein-Barr virus, cytomegalovirus, herpes zoster by a polymerase chain reaction in blood and tissues. All patients underwent determination of blood cytokines (tumor necrosis factor α,