Նեյրոպաթիկ Ցավի Կանխումը ՊիրոգլուտամիլԳԱԿԹ Դիպեպտիդով

Abstract

The analgesic activity of pyroglutamylGABA in combination with pregabalin was studied in neuropathic pain model of sciatic nerve chronic constriction injury. Rat’s pain behavior was studied using hot plate test. The investigated agents were administered intraperitoneally, at a dose of 20 mg / kg each, twice a day. Conducted experiments revealed the synergistic effect in analgesic activity of pyroglutamylGABA and pregabalin, which was confirmed by analysis of changes in frequency and latency of licking, jumping and locomotor activity of rats, caused by neuropathic pain. It is noteworthy that obtained analgesic action of investigated combination appears without sedation characteristic for pregabalin. Thus, the obtained data of synergism in analgesic action of pyroglutamylGABA and pregabalin combination could serve as a basis for preclinical trials for development of new agent for neuropathic pain management without side effects like sedation.