دراسة التغیرات الهستوباثولوجیة فى الفئران البیضاء المصابة بالسمنة باستخدام البابونج والجارسینیا مع تناول أوزان الأعضاء الداخلیة وبعض التغیرات الکیماویة الحیویة

Abstract

This study aimed to investigate the effect of chamomile (Matricaria chamomilla), garcinia (Garcinia cambogia) and mixture of both on histopathological structure along with internal organs weights and some biochemical changes of male obese rats. Thirty (30) adult male Sprague Dawley rats were divided into five groups. Group (1): Normal rats fed on basal diet as control negative (C-), Group (2): Control positive (C+) (untreated group). Group (3): Obese rats fed on basal diet and Chamomile (5%). Group (4): Obese rats fed on basal diet and Garcinia (5%). Group (5): Obese rats fed on basal diet and mixture of both (5%). At the end of experiment, after 28 days of feeding, all serum samples were analyzed for biochemical parameters. Overweight led to a significant (P ≤ 0.05) decrease in the level of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) while a significant (P ≤ 0.05) increase was recorded in leptin hormone & PFP. Obese rats treated with various diets showed the improvement in all previous parameters. Improvement was more pronounced for garcinia compared to chamomile diets, and the best group was recorded for the mix group, indicating a synergistic action.