一包化調剤後の酸化マグネシウム錠の保管に対する乾燥剤の有無が安定性に与える影響

Sato, Katsushige; Inaoka, Natsuko; Kodama, Yukinobu; Muro, Takahiro; Nakamura, Tadahiro; Sasaki, Hirokazu; Kitahara, Takashi

doi:10.1248/yakushi.18-00024

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…It has already been reported that the water permeabilities of cellophane polyethylene laminating paper at 20 μm and 30 μm and glassine paper are 3, 2, and 3 g/m 2 in 24 h (20 C, 60% RH) and 15, 11, and 16 g/m 2 in 24 h (30 C, 90% RH), respectively, by Yuyama, Ltd [9]. In magnesium oxide tablets, moisture absorption causes disintegration delay [6,10,11]. We have previously reported that the disintegration time of Magmitt ® 330 mg, packaged in 20 μm thick cellophane polyethylene laminating paper and stored at 25 C and 75% RH, is extended by approximately 51 s after 4 weeks and 9 min after 8 weeks compared with that of a non-packaged tablet (7 s) [12].…”

Section: Discussionmentioning

confidence: 99%

Relative humidity and qualities of hygroscopic medications stored in different one-dose packaging papers

Matsuo

Yoshida

Tomita

et al. 2020

Heliyon

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The one-dose package is useful for patients who are prescribed multiple medications. However, the one-dose packaging of hygroscopic medications is difficult because the quality of the medication is reduced by moisture absorption. Cellophane polyethylene laminating paper at 20 μm or 30 μm thickness and glassine papers are widely used for one-dose packaging. The basic characteristics, such as water permeability, of these packaging papers have been demonstrated by companies; however, the quality changes of hygroscopic medications stored in these packaging papers are poorly understood. In this study, we compared the relative humidity in packaging papers and the qualities of the stored hygroscopic medications among 20 μm and 30 μm thick cellophane polyethylene laminating paper and glassine paper. Glucobay® 50 mg, Magmitt® 330 mg, and Phosblock® 250 mg tablets were used as hygroscopic medications to be packaged and the relative humidity, weight change, and hardness of tablets were measured. The relative humidity decreased in the order of glassine paper, 20 μm thick cellophane polyethylene laminating paper, and 30 μm thick cellophane polyethylene laminating paper. Additionally, tablets inside the 30 μm thick cellophane polyethylene laminating paper gained the least weight. Therefore, tablets in a 30 μm thick polyethylene laminating paper absorb less moisture than those in other papers. However, the effect was less pronounced at high temperature, even if the relative humidity remained the same. We expect that the results will be used by hospitals and clinical pharmacies to understand the characteristics of packaging papers and ensure appropriate usage.

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Section: Discussionmentioning

confidence: 99%

Relative humidity and qualities of hygroscopic medications stored in different one-dose packaging papers

Matsuo

Yoshida

Tomita

et al. 2020

Heliyon

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“…1) In addition, there are some reports that the hardness and mass of MgO tablet formulations tend to increase when stored under humidified conditions and that disintegration of the MgO tablet formulations is prolonged by humidification. [2][3][4][5][6][7][8] Prolonged disintegration time of MgO tablet formulations affects patient's sense of taking. Furthermore, it is difficult for patients with insufficient swallowing ability to take the formulations.…”

Section: Introductionmentioning

confidence: 99%

Quality Evaluation of Humidified Magnesium Oxide Tablet Formulations with Respect to Disintegration Time Prolongation

Yamamoto

Ohgi

Onuki

et al. 2023

CHEMICAL & PHARMACEUTICAL BULLETIN

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In the present study, we conducted a detailed evaluation of the effects of humidification on the quality of five types of commercial magnesium oxide (MgO) tablet formulations. When near-IR spectroscopy was performed, a peak derived from the first overtone of the stretching vibration of the hydroxyl group was observed at approximately 7200 cm 1 in a humidified MgO tablet formulation. To visually evaluate the effect of this humidification, a mapping image was created using microscopic IR spectroscopy. In the IR spectrum, a peak derived from the stretching vibration of the hydroxyl group appears at approximately 3700 cm 1 , so we created a mapping image using the absorbance ratio of 3700 and 3400 cm 1 as an index. In the mapping image of humidified MgO tablet formulations, many areas had a higher absorbance ratio than the dried tablet formulations. From these results, it is qualitatively confirmed that the MgO was changed to magnesium hydroxide (Mg(OH) 2 ) by humidification. Although these results were observed in the four types of MgO tablet formulations, only one type of tablet formulation was less affected by humidification. In addition, although most tablet formulations tended to prolong disintegration time due to humidification, there was almost no effect of humidification on the disintegration time in one type of tablet formulation, which had little change in the above evaluation. Thus, in most commercial MgO tablet formulations, humidification prolongs the disintegration time, and Mg(OH) 2 significantly contributes to this factor.

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“…When hygroscopic medications are dispensed as one-dose packs, the storage of these medications with desiccating agents is important to retain their stability and efficacy [ 3 , 4 ]. However, the relationship between the quantity of desiccating agents and their safety when used in medication storage is poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Development of a novel moisture-suppression bag for the preservation of hygroscopic medications

Matsuo

Yoshida

Ushijima³

et al. 2023

J Pharm Health Care Sci

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Background One-dose packaging is frequently used in Japan for elderly patients who are prescribed several medications. It is useful for easy administration and the prevention of misuse or missed medications. Hygroscopic medications are not suitable for one-dose packaging because moisture absorption may alter their properties. Plastic bags with desiccating agents are sometimes used to store hygroscopic medicines in one-dose packaging. However, the relationship between the quantity of desiccating agents and their safety in the storage of hygroscopic medications is poorly understood. Furthermore, older adults might accidentally consume desiccating agents used in food preservation. In this study, we developed a bag that suppresses the moisture absorption of hygroscopic medications without the use of desiccating agents. Methods The bag was manufactured using polyethylene terephthalate, polyethylene, and aluminum film on the outside, and unified with a desiccating film on the inside. Results The relative humidity (RH) in the bag was maintained at approximately 30–40% when the bag was stored at 75% RH and 35 °C. The manufactured bag’s moisture suppressing effect was better than that of plastic bags with desiccating agents when the hygroscopic medications, potassium aspartate and sodium valproate tablets, were stored at 75% RH and 35 °C for 4 weeks. Conclusions The moisture-suppression bag effectively stored and preserved hygroscopic medications and was more effective in inhibiting moisture absorption than plastic bags with desiccating agents under high temperature and humidity conditions. The moisture-suppression bags are expected to be useful for elderly patients who are prescribed several medications in one-dose packaging.

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一包化調剤後の酸化マグネシウム錠の保管に対する乾燥剤の有無が安定性に与える影響

Cited by 5 publications

References 5 publications

Relative humidity and qualities of hygroscopic medications stored in different one-dose packaging papers

Relative humidity and qualities of hygroscopic medications stored in different one-dose packaging papers

Quality Evaluation of Humidified Magnesium Oxide Tablet Formulations with Respect to Disintegration Time Prolongation

Development of a novel moisture-suppression bag for the preservation of hygroscopic medications

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