抗SRY-Related HMG-Box Gene 1（SOX1）抗体陽性の舞踏運動の1例

Yamagishi, T.; Inoue, Kana; Ouchi, Haruka; Shibano, Ken; Hara, Kenju

doi:10.5692/clinicalneurol.cn-001454

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Anti-SOX1-Ab was found in eight of 55 (14.5%) patients with PNS, and the coexistence of anti-SOX1-Ab and anti-CV2/CRMP5-Ab was detected in one patient with paraneoplastic cerebellar degeneration in non-SCLC ( 12 ). There has only been one case of autoimmune chorea with anti-SOX1-Ab, but without anti-CV2/CRMP5-Ab, who had a 6-year prior history of lung adenocarcinoma with no recurrence or other cancer ( 13 ). In this case, hemichorea with anti-SOX1-Ab and anti-CV2/CRMP5-Ab was suggested to result from a tumor-induced immune response of SR associated with SCLC.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of Small Cell Lung Carcinoma and Associated Hemichorea

2021

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The spontaneous regression (SR) of cancer is defined as either partial or complete, and temporary or permanent, disappearance without appropriate treatment for the disease, and this phenomenon is rare in the case of small cell lung carcinoma (SCLC). We herein report an 83-year-old woman who presented with left-sided hemichorea associated with anti-SOX1 (SOX1-Ab) and -CV2/CRMP5 (CV2/CRMP5-Ab) antibodies with SR following a 7-year interval free of disease progression of SCLC. Hemichorea can present with the coexistence of anti-SOX1 and CV2/CRMP5-Ab with SR after a long interval free of SCLC. The immune response associated with these onco-neural antibodies may become independent of the original tumor trigger and remain active for many years.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of Small Cell Lung Carcinoma and Associated Hemichorea

2021

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“…Chorea in synaptic (idiopathic and paraneoplastic) autoimmune encephalitis is possible, but rarely isolated. GAD65-AK; CASPR2-Ab; NMDA-R-AK; CRMP-5 IgG [108], N-type or P/Q-type calcium channel antibodies [17,70]; Anti-SOX1-Ab [117], LGI-1-Ab (30-60 highfrequency, short daily brachiofacial dystonic seizures per day preceding or paralleling limbic encephalitis), and probably also other autoimmune, partly post-infectious or -vaccine encephalitis, e.g. B. IgLON5-Ab (usually with sleep disorders and stridor); [39,60,74,88,110].…”

Section: Autoimmune and Paraneoplastic Choreiform Syndromesmentioning

confidence: 99%

Differential diagnosis of chorea (guidelines of the German Neurological Society)

Saft,

Burgunder,

Dose

et al. 2023

Neurol. Res. Pract.

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Introduction Choreiform movement disorders are characterized by involuntary, rapid, irregular, and unpredictable movements of the limbs, face, neck, and trunk. These movements often initially go unnoticed by the affected individuals and may blend together with seemingly intended, random motions. Choreiform movements can occur both at rest and during voluntary movements. They typically increase in intensity with stress and physical activity and essentially cease during deep sleep stages. In particularly in advanced stages of Huntington disease (HD), choreiform hyperkinesia occurs alongside with dystonic postures of the limbs or trunk before they typically decrease in intensity. Summary or definition of the topic The differential diagnosis of HD can be complex. Here, the authors aim to provide guidance for the diagnostic process. This guidance was prepared for the German Neurological Society (DGN) for German-speaking countries. Recommendations Hereditary (inherited) and non-hereditary (non-inherited) forms of chorea can be distinguished. Therefore, the family history is crucial. However, even in conditions with autosomal-dominant transmission such as HD, unremarkable family histories do not necessarily rule out a hereditary form (e.g., in cases of early deceased or unknown parents, uncertainties in familial relationships, as well as in offspring of parents with CAG repeats in the expandable range (27–35 CAG repeats) which may display expansions into the pathogenic range). Conclusions The differential diagnosis of chorea can be challenging. This guidance prepared for the German Neurological Society (DGN) reflects the state of the art as of 2023.

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抗SRY-Related HMG-Box Gene 1（SOX1）抗体陽性の舞踏運動の1例

Abstract: A case of anti-SRY-Related HMG-Box Gene 1 (SOX1) antibody-positive chorea

Cited by 2 publications

References 22 publications

Spontaneous Regression of Small Cell Lung Carcinoma and Associated Hemichorea

Spontaneous Regression of Small Cell Lung Carcinoma and Associated Hemichorea

Differential diagnosis of chorea (guidelines of the German Neurological Society)

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