海洋天然产物抗iav活性及作用机制研究进展

Abstract

The influenza A virus (IAV) is a highly infectious RNA virus that has a significant impact on human health due to its rapid mutation rate and high incidence. Currently, the anti-IAV drugs used in clinical settings, such as amantadine, oseltamivir, and peramivir, have shown drug resistance, leading to a potential threat of widespread resistance and a lack of effective treatment options. Therefore, the development of new antiviral medications effective against drug-resistant IAV is urgently needed. Marine natural products, with their unique structures and significant bioactivities, serve as an important source for screening lead compounds in the development of anti-IAV drugs.In particular, marine-derived anti-IAV compounds exhibited diverse targets and unique mechanisms, offering a promising approach to addressing the issue of drug resistance in IAV medications. This review summarized the marine-derived anti-IAV natural products, including their structural characteristics, activity diversity, and antiviral mechanisms. The findings could provide valuable insights for the development of novel and targeted drugs against drug-resistant IAV.