:Increasing energy efficiency can reduce energy consumption and promote sustained economic growth in all countries. The coordinated development of energy efficiency and high quality economic growth is an essential requirement for enhancing the well-being of people in all countries. This study used Directional Distance Function (DDF) and Global Malmquist-Luenberger (GML) index to calculate the energy efficiency of 50 countries along the Belt and Road initiative region from 1995 to 2015, and constructed a model to explore the"decoupling"relationship between economic growth and energy consumption and energy efficiency. The study found that: (1) From 1995 to 2015, the overall energy efficiency of the countries in the Belt and Road region averaged 0.682, first falling then rising, reaching a peak of 0.833 in 2008, and then fluctuating with a falling trend; (2) In 1995-2015, energy efficiency of these countries increased by 17.5%. The catch-up efficiency and technological progress contribution rates were 7.2% and 10.0% , respectively, which jointly promoted the improvement of energy efficiency. Except for the negative growth of the Commonwealth of Independent States (CIS), Energy efficiency in other regions has increased to varying degrees; (3) Decoupling between economic growth and energy consumption and energy efficiency of the Belt and Road countries is determined by continuing to reduce energy consumption, improve energy efficiency, and promote economic growth, and it has gone through a process of drifting away from weak decoupling, weak decoupling, and again drifting away from weak decoupling. Therefore in the future, countries should start with focusing on catching-up efficiency and technological progress, improve energy efficiency, and achieve a strong decoupling between economic growth and energy consumption, a weak decoupling between economic growth and energy efficiency, or a negative decoupling relationship.