This study aims to evaluate the effect of different graded levels of local and imported yeast (Saccharomyces cerevisiae) on growth performance of African catfish, Clarias gariepinus. A total of 250 fingerlings of the African catfish Clarias gariepnus were collected from Edku Lake for the experiment. The fish were divided into 5 groups, containing of 50 fish in each group. Describe the group and treatment given to each group of the fish. The results showed that the supplementation of local yeast, improved the growth and feed utilization. Significant results were recorded for treatment of G2 compared to the G1. It was shown that the yeast supplementation significantly affected the whole-fish body composition. All treatments exhibited higher values compared to the G1. Treatment of G2 also showed the lowest values for dray matter, ether extract and ash content, while it showed highest value for crude protein compared to the G1. Hematological analysis of all the treatments showed satisfactory values compared to the G1. From the economic point of view, the utilization of local baker's yeast for African catfish could reduce the cost, while increases the growth and production performance under farming conditions.