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Background: Impairment of gas exchange is a common problem during one lung ventilation (OLV) with a hazardous effect on morbidity and mortality. The current study compares the effect of volume-controlled ventilation (VCV) versus pressure-controlled ventilation volume guaranteed (PCV-VG) on gas exchange during OLV. Settings and Design: This study was a prospective randomized study. Methods: The study was carried out on 30 adult patients who were randomly assigned to two groups. Group VCV: VCV was performed throughout the operation. Group PCV-VG: PCV-VG was performed throughout the operation. Haemodynamic parameters ((HR), MAP), and (CVP)), blood gas analysis, and PaO 2 /FiO 2 were recorded: before induction of anaesthesia (T0); during TLV (T1); ½ an hour after OLV (T2); 1 h after OLV (T3); 20 minutes after resuming TLV (T4); 6, 12, and 24 hours after surgery (T5, 6, and T7). (Ppeak), (Pmean) and (Cdyn) were recorded during (T1, 2, 3, and T4) time intervals. TNFα level was measured in venous Samples in the following times: (1) before induction of anaesthesia (T0); (2) Directly after surgery (T1); (3) 5 th postoperative day (T2). The patients were followed for 5 days for recording of PPCs. Results: PCV-VG ventilation leads to a significant decrease in Ppeak and Pmean and significant increase in Cdyn (P ≤ 0.05). However, it had no effect on intra-and postoperative oxygenation values. Conclusion: PCV-VG is superior to VCV as regard respiratory dynamics during one lung ventilation (OLV), while it does not differ as regard items of gas exchange, inflammatory response and PPCs.

Conclusions This report describes three cases of SIH with CSF leak originating from the cervical, the thoracic and the lumbar level. The EBP restored CSF volume and relieved the patients' persistent symptoms. EBP is a well-accepted and beneficial treatment modality for SIH when conventional measures fail.

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