Любое клинически значимое инфекционное заболевание, развившееся у человека в результате его пребывания в условиях лечебного учреждения независимо от степени оказанной ему медицинской помощи, принято называть инфекциями, связанными с оказанием медицинской помощи (ИСМП). В настоящее время данной патологии принадлежит одно из ведущих мест в структуре смертности в стационаре, она определяет значительное увеличение сроков пребывания пациента в лечебном учреждении и повышает стоимость его лечения. Возникшая в результате ИСМП потеря трудоспособности человека наносит весомый экономический ущерб государству, больному и его семье [1].

Introduction In 2002, the Surviving Sepsis Campaign defi ned a strategy that aimed to reduce the high mortality due to sepsis. One point of this strategy was a recommendation to recognize that sepsis is a frequent cause of death and high economic costs in the pediatric intensive care unit. Knowledge of the disease is the fi rst step to impact it. There are few studies on pediatric sepsis epidemiology in the world and none in Colombia. Hypothesis The epidemiological features of Colombian children are diff erent from other countries. Methods We constructed a website where 14 intensive care units across the country reported in a prospective way the epidemiological features of children with sepsis using an electronic process [1]. We asked for sociodemographics, microbiological data, sepsis classifi cation, complications, and outcome. Results We collected 253 patients from March to May 2009. Fifty-fi ve percent of the cases were male and 45% were female; 53% were less than 1 year old. A total of 67.2% came from urban areas and 33% came from rural villages. Eighty-fi ve percent were very poor (score 1 and 2 over 6 used in Colombia as socioeconomic classifi cation). Forty-fi ve percent have governmentsupported insurance. In total, 23.72% of the population presented with sepsis; 30.04% with severe sepsis; and 46.5% with septic shock. The infection origin was respiratory in 54.55%, followed by abdominal in 17.39%. In 50.2% no cause was identifi ed. A total of 75.1% required mechanical ventilation. The mortality rate was 20.4%. Conclusions Sepsis, severe sepsis, or septic shock is a common diagnosis in Colombian intensive care units. The majority of pediatric patients are 2 years or younger and from the poorest communities. It aff ected males more. In the majority, the process starts in the respiratory system. We had diffi culty identifying the cause. The disease causes high mortality and cost for a developing society. We need a complete survey to fi nd a correct approach to the problem. Reference 1. Sepsis en Columbia [www.sepsisencolombia.com] P2 Randomized controlled trials are not designed to prove the safety of third-generation hydroxyethyl starch for resuscitation: results from a systematic review

The 45-day experience of an infectious diseases hospital for providing care to patients with COVID-19, deployed on the basis of a multifunctional surgical center, was analyzed. It was shown that more than 30% of patients required intensive care, of which 50.6% required prolonged mechanical ventilation (ALV). The most severe group consisted of patients aged> 80 years (13.5%) and a body mass index> 40 kg / m 2 (21.8%). The treatment used standards 5 and 6 recommendations of the Ministry of Health of the Russian Federation. Non-invasive ventilation (NIV) was performed in 17.9%, high-flow oxygenation (HPO) in 33.9%. 69% were weaned from endotracheal mechanical ventilation, 19.8% of them through tracheostomy. The overall mortality rate was 4.8% (mainly women -55%, with obesity -36.8% and in old age -45% of all deaths), resuscitation mortality -12.8%. The effectiveness of the consistent application of respiratory support methods and the use of separate components of the fasttrack techniques for compulsory mechanical ventilation, extracorporeal treatment methods and tocilizumab for cytokine storms has been demonstrated.

Organ dysfunction assessment by Sepsis-3 criteria improves diagnostic possibilities in patients with suspected sepsis. Maximum predictive value is observed for systemic inflammation response combined with organ dysfunction. In these patients procalcitonin and presepsin are characterized by equivalent high diagnostic potential for evidence of infectious nature of the disease. Increased level of these markers can serve as a basis for antimicrobial therapy administration.

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