On the basis of periodontal indices, the anti-plaque and anti-inflammatory effect of the gel composition of the new domestic drug, the main active ingredient of which is dihydroquercetin contained in the bark of Siberian larch, which has an antioxidant and antihypoxant effect, was studied. From practically healthy patients aged 18 to 40 years with inflammatory changes in the marginal periodontium (with chronic catarrhal gingivitis and mild periodontitis) without serious concomitant diseases, 2 groups were formed — control (group "A") and experience (group "B"), 30 people in each group. Patients were not separated by gender. At the first stage, patients were taught the rules of brushing their teeth and hygienic care of the oral cavity using demonstration phantoms. Then, after antiseptic treatment of the marginal periodontium and application anesthesia, dental deposits were removed for patients of both groups. At this point, treatment intervention for patients in the control group (Group B) was limited. Patients of group A were additionally prescribed applications of a therapeutic gel. Patients applied the drug to the gums previously dried with a cotton swab from the outer and inner surfaces on their own with a frequency of 3 times a day after demonstrating the rules for the procedure and monitoring by the specialist the correctness of its implementation by the patients themselves. The clinical condition of the soft tissues in patients of both groups was monitored before the start of treatment, after 3, 7 and 14 days based on a number of indices: Silness-Loe, PMA and Mulleman). The Muhleman Index values in patients before treatment in both groups were 2.4±0.5 and 2.3±0.5 c.u. (conventional unit)., respectively. In subsequent terms, after 3, 7 and 14 days, the index values progressively decreased. 3 days after the removal of dental deposits, the index values significantly decreased: to 1.7±0.5 c.u. in the first and up to 1.9±0.6 c.u. in the second (p<0.05) group of patients. After 7 days, the bleeding index progressively decreased also in both groups, but less intensively. Moreover, the index in patients in group A was 1.1±0.4 and in patients in group B 1.5±0.5 and 0.5±0.1 c.u. Most clearly, the difference in the effect manifested itself on the 14-th day: 0.5±0.3 units. in patients of group A and 1±0.5 c.u. in patients in group B (in all cases p<0,05). The dynamics of the RMA inflammation index turned out to be very comparable with the dynamics of the Muhleman index in patients of both groups. The initial training in the rules of brushing the teeth made it possible to achieve an ideal cleansing of the oral cavity in both groups of patients, and the achieved effect was maintained throughout the study period. This confirmed the decrease in the Silness-Loe plaque index to almost zero, despite the fact that before the start of the study its values were the same and reached almost the maximum value: 2,4 c.u. in patients. of both groups. Characteristically, after 3 days, the index value in patients in both groups decreased almost identically to a value of 0.8 c.u., and after 7 and 14 days — almost to zero. This fact allowed us to attribute the achieved anti-inflammatory effect not due to more thorough brushing of teeth during the experiment, but precisely due to the therapeutic effect of the applied gel. The presented numerical data of clinical indicators were confirmed by the results of statistical processing using the Student's method with the determination of the reliability criterion. Examination and questioning of patients made it possible to establish the absence of negative clinical and organoleptic sensations from the use of the gel in patients of both groups. The data obtained made it possible to establish a pronounced anti-inflammatory effect of the therapeutic gel "Flamena stom." and to recommend the gel for use in wide clinical practice as part of the complex treatment of patients with inflammatory periodontal diseases.

On the basis of periodontal indices, the anti-plaque and anti-inflammatory effect of the gel composition of the new domestic drug, the main active ingredient of which is dihydroquercetin contained in the bark of Siberian larch, which has an antioxidant and antihypoxant effect, was studied. From practically healthy patients aged 18 to 40 years with inflammatory changes in the marginal periodontium (with chronic catarrhal gingivitis and mild periodontitis) without serious concomitant diseases, 2 groups were formed — control (group "A") and experience (group "B"), 30 people in each group. Patients were not separated by gender. At the first stage, patients were taught the rules of brushing their teeth and hygienic care of the oral cavity using demonstration phantoms. Then, after antiseptic treatment of the marginal periodontium and application anesthesia, dental deposits were removed for patients of both groups. At this point, treatment intervention for patients in the control group (Group B) was limited. Patients of group A were additionally prescribed applications of a therapeutic gel. Patients applied the drug to the gums previously dried with a cotton swab from the outer and inner surfaces on their own with a frequency of 3 times a day after demonstrating the rules for the procedure and monitoring by the specialist the correctness of its implementation by the patients themselves. The clinical condition of the soft tissues in patients of both groups was monitored before the start of treatment, after 3, 7 and 14 days based on a number of indices: Silness-Loe, PMA and Mulleman). The Muhleman Index values in patients before treatment in both groups were 2.4±0.5 and 2.3±0.5 c.u. (conventional unit)., respectively. In subsequent terms, after 3, 7 and 14 days, the index values progressively decreased. 3 days after the removal of dental deposits, the index values significantly decreased: to 1.7±0.5 c.u. in the first and up to 1.9±0.6 c.u. in the second (p<0.05) group of patients. After 7 days, the bleeding index progressively decreased also in both groups, but less intensively. Moreover, the index in patients in group A was 1.1±0.4 and in patients in group B 1.5±0.5 and 0.5±0.1 c.u. Most clearly, the difference in the effect manifested itself on the 14-th day: 0.5±0.3 units. in patients of group A and 1±0.5 c.u. in patients in group B (in all cases p<0,05). The dynamics of the RMA inflammation index turned out to be very comparable with the dynamics of the Muhleman index in patients of both groups. The initial training in the rules of brushing the teeth made it possible to achieve an ideal cleansing of the oral cavity in both groups of patients, and the achieved effect was maintained throughout the study period. This confirmed the decrease in the Silness-Loe plaque index to almost zero, despite the fact that before the start of the study its values were the same and reached almost the maximum value: 2,4 c.u. in patients. of both groups. Characteristically, after 3 days, the index value in patients in both groups decreased almost identically to a value of 0.8 c.u., and after 7 and 14 days — almost to zero. This fact allowed us to attribute the achieved anti-inflammatory effect not due to more thorough brushing of teeth during the experiment, but precisely due to the therapeutic effect of the applied gel. The presented numerical data of clinical indicators were confirmed by the results of statistical processing using the Student's method with the determination of the reliability criterion. Examination and questioning of patients made it possible to establish the absence of negative clinical and organoleptic sensations from the use of the gel in patients of both groups. The data obtained made it possible to establish a pronounced anti-inflammatory effect of the therapeutic gel "Flamena stom." and to recommend the gel for use in wide clinical practice as part of the complex treatment of patients with inflammatory periodontal diseases.

On the basis of clinical periodontal indices of Muhlemann, RMA and Silness-Loe, the effectiveness of a new water-soluble form of the immunomodulatory drug Superlimf L in the treatment of inflammatory periodontal diseases was studied. Material and methods. 2 groups of patients with moderate periodontitis were formed: the experimental group (Group A) and the control group (Group B) (30 patients in each group). Before the start of treatment, all patients were taught the rules of correct brushing. Piezon-Master-400 and polishing the surfaces of the roots of the teeth in patients of the experimental group (A) were introduced into the periodontal pockets on cotton turundas with a solution of Superlimf® L. Previously, the pulvis of the Superlimf® L was dissolved in 5 ml of distilled water. Cotton turundas soaked in the preparation solution were introduced into periodontal pockets and soaked swabs were applied to the surfaces of gum — for 40 minutes. The procedures were carried out daily for 2 weeks. In the control group, the intervention was limited to the removal of dental deposits and subsequent controlled brushing of the teeth once every 3 days. The duration of the study was 2 weeks. An index assessment of the periodontal condition in patients of both groups was performed before treatment and, 3, 7 and 14 days after treatment. Treatment results. Clinically visible improvement in the condition of periodontal tissues after mechanical treatment occurred in patients of both groups after 3 days. The dynamics of the Silness-Loe index was very demonstrative in patients of both groups. Being initially almost equally high (2.35±0.45 units), after 3 days these values decreased by more than half. However, the difference in the decrease in the value of the Muhlemann index and PMA in patients of groups A and B was very significant. If in the control group (group B) after 3 days the intensity of bleeding during a probe test decreased by no more than 20%, then in patients in group A it decreased by almost half. In subsequent periods of observation, the decrease in inflammation and bleeding indices was also almost 3 times more intense in patients in group A than in patients in the control group. It is characteristic that the Silness-Loe plaque index already on the 7th day in patients in group B was significantly higher than in patients in group A. By the end of the study, both clinically and according to the index assessment of the condition of the periodontium in patients who received Superlimf® L, the condition of periodontal tissues was significantly better than in patients in the control group (Group B). Conclusion. Pronounced efficacy, the absence of adverse effects when using the product, good organoleptic indicators — all of the above allows specialists to use the powder form of the new drug Superlimf® L for the treatment of inflammatory periodontal diseases both in the conditions of dental units, as well as recommend to patients after their preliminary instruction and training apply the remedy at home.