During the COVID-19 pandemic it became known that SARS-CoV-2 virus has other targets beside lungs. Recent studies imply that the virus have shown tropism on kidneys, which under the durable kidney disease leads to aggravation of chronic kidney disease (CKD). The article presents a case of progressive CKD in a patient of the Nephrology Department at Republic Clinical Hospital who had two prior cases of COVID-19. Initially he had the 3A stage of CKD with GFR 58 ml/min/1.73 m2, with proteinuria level of A1 stage. After the first COVID-19 infection, his GFR decreased to 40 ml/min/1.73 m2. After the second COVID-19 infection, GFR decreased to 34.2 ml/min/1.73 m2 and proteinuria reached the A3 stage levels. After six months, GFR was 21.5 ml/min/1.73 m2, and proteinuria reached nephrotic levels. The presented case showed progression of CKD due to SARS-CoV-2.