Introduction Psychological distress is a phenomenon that often occurs not only in patients but in normal subjects under excessive psychological pressure. Health care workers are at particular risk of distress in a pandemic. It negatively affects the quality of life, social and physical functioning and can be a trigger of different diseases. The pharmaceutical drugs can be unnecessary active for healthy subjects. Nutraceuticals may be the adequate choice in this situation. Objectives Assessing the effectiveness of the unique antistress combination of the three herbal ingredients (standardized extracts of passionfruit, melissa and catnip) in medical workers with the signs of psychological distress Methods Twenty-four subjects-medical doctors from 30 to 55 years old (15 women; 9 men) were included into the one-week study. Antistress combination was administered 1 tablet tid. The first part of the State-Trait Anxiety Inventory (STAI “State anxiety”) andor a free self-report were done twice (before and at the end of the study) Results From 24 subjects 19 subjects filled out the STAI, free self-reports were received from 10 subjects (5 people provided information about their condition in two forms). STAI scores showed statistically significant decrease in anxiety at the end of the study. A positive effect the emotional condition and quality of sleep was noted in free self-reports. Adverse effects of nutraceuticals were rare, mild, and transient. No negative impact on quality of working condition was registered. Conclusions The pilot study showed the promising effect of antistress combination in medical workers in specific stressful situation. Disclosure No significant relationships.

Introduction Chronic functional gastro-intestinal disorders can affect cognitive functioning of patients (1). Wong et al (2) showed attentional and executive function impairment, Aizawa et al. (3) found impairment of cognitive plasticity and activity of frontal and temporal arias of brain during performing tests in these patients. Objectives Assessing of cognitive functioning of the female patients with chronic functional constipation. Methods 42 Rome IV adult female patients with chronic functional constipation and 26 adult normative female volunteers were tested with Brief Assessment of Cognition in Schizophrenia (BACS). Results Both groups were comparable by age (patients’ group 29,5±6,1, volunteers’ group 28,5±9,6, ns) In both groups subjects demonstrated normal level of cognitive functioning but the scores of the patients were closer to the lower level than the scores of the volunteers. The difference was significant in composite scores and in several other scores (Tab.1). Table1. BACS Patients (n=42) Volunteers (n=26) p-level Verbal Memory 49,5± 10,6 58,8± 7,1 0,0002 Work memory 48,2±10,1 51,7±8,4 ns Motor token 51,3±10,5 59,8±10,4 0,003 Verbal fluency 52,1±11,5 56,5±9,9 ns Symbol coding 45,1±8,4 54,8±12,7 0,015 Tower of London (planning) 50,2±10,7 57,6±10,2 0,015 Composite scores 49,1 ±10,1 59,9 ±7,4 0,0001 Conclusions The findings of the study once more indicate some link between gastrointestinal dysfunction and cognitive functioning. Even these slight decrease in some aspects of cognition from normal population could have negative impact on everyday functioning. The origin of this link is still under question. Disclosure No significant relationships.