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Background: The quality of life of patients with Cutis Verticis Gyrata (CVG) has not been previously investigated in the literature. Objective: Description of features and evaluation of quality of life of CVG patients. Materials and methods: We employed a mixed methods study. We retrospectively collected data from the clinical database from 2012 to 2020. We selected 17 clinically diagnosed CVG patients and prospectively evaluated the quality of life of these CVG patients. Results: Out of 13 patients, 11 patients were in between the 14-47 age group. The majority of them were male (77%), Caucasian (54%), had no significant family history (92.3%), and had the age of onset below < 30 years (69.2%). The majority of the patients had a secondary form of CVG (54%) followed by a primary essential form of CVG (46.1%). The CVG had a small effect on the majority of patient's quality of life (77%), and a majority of patients were not taking any treatment (69.2%) Conclusion: In our study, the CVG was shown to have a small effect on the patient's quality of life.