It is known that chromosomal abnormalities are one of the most important causes of the spontaneous abortions. In this review we have considered the cytogenetical disturbances which can lead to miscarriages and embrio losses at assisted fertilization technologies. We have analyzed the structure of chromosome aberrations in spontaneous abortions and influence of the different types of alterations on the forecasting the future pregnancy outcomes. It has been considered the probability of recurrence of the pregnancy losses in patients-carriers of structural balanced chromosome rearrangements. In vitro fertilization implantation failures like as the miscarriages can depend on presence of chromosome anomalies including the occasions when the parents are the carriers of structural unbalanced rearrangements. So the kariotyping of couples, which require the assisted fertilization technologies, should be the necessary part of preliminary investigation.

Цель статьи: представить клинический случай ведения беременной с диагнозом рака желудка (РЖ), акцентировать внимание на диагностичес ком поиске и выборе тактики лечения. Основные положения. У пациентки Н., 22 лет, на сроке 33 2/7 недель беременности диагностирован РЖ сT3NxM0 G3, HER-2/neu негативный. Учитывая диагностированный РЖ (перстневидно-клеточный морфологический вариант), срок беременности, гарантирующий рождение жизнеспособного плода, было решено родоразрешить беременную путем кесарева сечения. На 5-е сутки послеродового периода больная переведена в специализированный онкологический центр для дальнейшего лечения и проведения индукционной (предоперационной) полихимиотерапии. Проведены два цикла химиотерапии по стандартной схеме FLOT с эффектом частичного регресса. Далее выполнены расширенная гастрэктомия с лимфодиссекцией D2 и три цикла послеоперационной полихимиотерапии по такой же схеме. Заключение. Подход к лечению пациенток, имеющих онкологические заболевания на фоне беременности, должен быть мультидисциплинарным, их должны вести совместно акушер-гинеколог и онколог с соответствующим клиническим опытом и современными знаниями, что позволит своевременно, с учетом срока беременности, стадии заболевания, с минимизацией рисков для матери и плода определить тактику ведения беременной, а также сроки и способ родоразрешения. Ключевые слова: рак желудка, беременность, клинический случай.

In gynecologic patients with internal genitalia diseases (endometriosis, uterine myoma) the frequency of mammal hyperplasia makes up to 60- 95%. The research aim was to study the effectiveness of conservative therapy with gestagens (norcolut, orgametril) application in benign hyperplastic mammal processes management in patients with uterine myomas. The effectiveness of gestagens application in patients with uterine myomas with coexisting dyshormonal mammal hyperplasia is proved.

The Brief Clinical Practice Guidelines are a study guide that provides the most relevant information about the new coronavirus infection - COVID-19. The recommendations were developed by a working group created under the Governor of St. Petersburg, which included experts - obstetricians-gynecologists, anesthesiologists-resuscitators, clinical pharmacologists, cardiologists, healthcare organizers, as an information resource for specialists working in the field of maternal and child health. The publication is intended for doctors - obstetricians-gynecologists, anesthesiologists-resuscitators, emergency doctors and other specialists working in the field of providing medical care to pregnant women, women in labor and postpartum women in St. Petersburg and the Northwestern Federal District, as well as clinical residents.

The experience of combined application of hysteroscopy and laparoscopy in treatment of infertile women is analyzed. An alternative technique of treating occlusion of the uterine tubes with the method of their transcervical recanalization using ureteral catheter is represented. The statement is made about the perspectives of applying combined hysteroscopy and laparoscopy in treatment of patients with infertility.