Abstract-This study evaluated the effect of combining autogenous bone with synthetic bioactive glass -hydroxyapatite in the treatment of vertical periodontal defects. Ten subjects with chronic periodontitis were treated in a split mouth design with either a combination of bioactive glass -hydroxyapatite and autogenous bone or bioactive glass-hydroxyapatite alone. Clinical and radiographic parameters showed significant improvement within groups in the soft and hard tissue parameters assessed at six months. However, there was no statistically significant difference between the groups. Only marginal benefits were observed on addition of autogenous bone to the synthetic graft.Index Terms-Autogenous cortical bone particulate, bioactive glass, periodontal defects, chronic periodontitis.