No abstract

No abstract

No abstract

No abstract

no hand OA. No significant differences were observed for cortical (Ct) parameters (CtvBMD, Ct thickness and porosity). After adjustment for age and BMI, each SD increase of trabecular and strength parameters (Tt.vBMD, Tb.vBMD, FL and K at both sites and Tb.N at the radius) was significantly associated with an increased risk of hand OA with adjusted ORs between 1.32 and 1.51 (p¼0.02 to p¼0.003). For comparison, each T score increase of Total Hip aBMD was associated with an increased risk of hand OA with an adjusted OR of 1.23 (p¼0.05). During a median[IQ] 10[1.1] yr of follow-up, 138 women sustained an incident fragility Fx. After adjustment for age, BMI, previous Fx and Total Hip BMD, no significant association was found between hand OA and the risk of incident Fx (adjusted hazard ratio [95%IC] of 0.93 [0.64-1.35]. Conclusions: Hand OA is associated with a better bone MA in postmenopausal women, particularly for trabecular compartment and strength. The absence of a protective effect from incident fragility fractures despite improved BMD and architecture suggests an impairment in other aspects of bone quality.