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The results of this study demonstrated that once-daily nifedipine in GITS formation and amlodipine are comparably safe and effective treatment options in patients with mild-to-moderate essential hypertension.

The effect of nifedipine on serum theophylline levels in 13 female hypertensive patients having asthma on theophylline therapy has been investigated. Administration of a slow release theophylline product in a dose of 200 mg bidaily for 15 days provided a steady-state through serum theophylline concentration (11.2 +/- 2.7 micrograms/ml). After this period, 10 mg bidaily nifedipine was added to therapy and trough serum theophylline levels, pulmonary function tests and blood pressure measurements have been performed following 15 and 45 days of simultaneous use of theophylline and nifedipine. No change has been observed in serum theophylline level after 15 days of simultaneous use, however after 45 days, serum theophylline level was significantly lower (7.3 +/- 1 micrograms/ml). There were no changes in clinical responsiveness of either of these drugs.

Abstract. The antagonistic effect of aspartic acid on some effects of morphine is known. This is mainly seen in the development of dependence on and tolerance to morphine. We investigated the mutual effects of the two drugs on the brain levels in mice.A total of 120 mice were examined in two groups. One group was given an intraperitoneal injection of tritiated aspartic acid. The other group was given tritiated aspartic acid and aspartic acid (30 mg/kg). Thirty mice in each group were injected with 15 mg/kg of morphine i.v. simultaneously. Thus we obtained four different groups of mice. Ten mice from each group were killed after a time elapse of 15, 30, and 60 min consecutively, and the morphine content and radioactivity on their brains were determined. Other samples of brain homogenates were deproteinized and their radioactivity was measured.Morphine increased the brain levels of labeled aspartic acid, while the brain content of morphine was decreased. It was thought that the results might be related rather to a heteroexchange existing between the morphine content in the central nervous system (CNS) and aspartic acid in the circulation. In addition aspartic acid can possibly stimulate or inhibit the efflux or influx of morphine in the CNS.

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