Background Heart rate-corrected (QTc) interval may increase in the setting of ST-elevation myocardial infarction (STEMI) even after complete reperfusion of the infarct-related artery. The remaining ischemia affects ventricular repolarization and may be associated with an increased susceptibility for malignant ventricular arrhythmias. Two-dimensional (2D) speckle tracking echocardiography (STE) is an angle-independent technique for evaluating myocardial function. The study aimed to analyze the layers specific strain using STE in patients after percutaneous coronary intervention (PCI) and find a possible correlation with QTc interval. Methods 74 patients with STEMI and TIMI 3 flow after PCI were enrolled. The study did not include patients with bundle branch block, pacing, or treated with drugs that could increase the QTc interval. The evaluation consisted of clinical examination and laboratory tests. 12 leads electrocardiography evaluated QTc interval. Echocardiographic acquisitions were performed in the first 24–48 hours after PCI, and data were analyzed on the workstation. The global longitudinal strain was measured from apical views, at the level of the endocardium GLSAvgEndo, transmural GLSAvg, epicardium GLSAvgEpi; the difference bewtwen endocardium and epicardium longitudinal strain: GLSAvgEndo-GLSAvgEpi. Layer-specific GLS values were measured as the average of the longitudinal strain of 17 LV segments at each individual layer (Figure 1). Results Patients were diveded in two groups: the first included 32 patients with a single vessel disease (43.24%) and the second, 42 patients (56.75%) with multiple vessel damage, but without other indication for revascularization except the culprit lesion. Values for layers strain and QTc interval in the first group were: GLSAvgEndo: −16.2 (SD 2.98, CV 0.18), GLSAvg: −11.46 (SD 6.98, CV 0.6), GLSAvgEndo-GLSAvgEpi: 3.54 (DS 1.06, CV 0.29), QTc: 452.5 (SD 22.65, CV 0.05) and in the second group: GLSAvgEndo: −13.22 (SD 4.01, CV 0.3), GLSAvg: −11.3 (SD 3.39, CV 0.29), GLSAvgEndo-GLSAvgEpi: 3.47 (CV 1.28, CV 0.37), QTc: 490ms (SD 43.07, CV 0.08). QTc interval correlated with and layers strain in the first group: GLSAvgEndo: r=0.56, GLSAvg: r=0.67, GLSendo-GLSepi: r=0.54, and in the second group: GLSAvgEndo: r=0.73, GLSAvg: r=0.75, GLSAvgEndo-GLSAvgEpi: r=0.62. Conclusions 1. The present study identified decreased longitudinal strain in all myocardial layers in the first days after STEMI, even after a successful PCI. 2. Alterations of QTc dynamicity were more frequent in patients with multivessel lesions 3. The electrical instability related by QTc interval correlated with the myocardial tissue damage related by STE. The correlation was more evident in patients with multivessel disease, even with remaining nonsignificant lesions, suggesting an ongoing process of microcirculatory perfusion damage. Funding Acknowledgement Type of funding sources: None.

Background 4-Dimensional Automated Left Atrial Quantification (4D Auto LAQ) is a technique that uses 3D volume data to determine LA strain. 4-Dimensional Automated Mitral Valve Quantification (4D Auto MVQ) evaluates anatomical and functional mitral valve parameters. Our study evaluated patients with dilated cardiomyopathy and tried to find a correlation between LA strain and mitral apparatus geometry. Methods We enrolled 61 patients with dilated cardiomyopathy and 25 healthy volunteers. The evaluation consisted of clinical examination, laboratory tests, 12 leads electrocardiography. All participants underwent a complete transthoracic echocardiogram to determine cardiac structure and function according to the current guidelines. Measurement of LA strain and MV was performed using 4D Auto-quantification software. The study evaluated longitudinal strain during reservoir phase (LASr) and the parameters of the MV geometry that could interfere with left atrial function: annulus area, annulus perimeter, anteroposterior (A-P) diameter, posteromedial-anterolateral diameter (PM-AL), (the longest diameter of MV perpendicular to AP diameter); commissural diameter (CD), inter-trigonal distance, tenting height, tenting area, and tenting volume. Results 1. The patients were divided in two groups: 26 with ischemic dilated cardiomyopathy and 35 with non-ischemic dilated cardiomyopathy. 2. Mean values of MV parameters in patients with dilated cardiomyopathy compare with healthy volunteers were: annulus area: 19.46 cm2 vs 11.85 cm2; annulus perimeter: 16.86 cm vs 12.71cm, A-P diameter 4.53 cm vs 3.45 cm, PM-AL diameter 4.84 cm vs 3.92 cm, CD 4.83 cm, vs 3.94 cm, inter-trigonal distance 3.9 cm vs 2.9 cm, tenting height 1.64 cm vs 1.05 cm, tenting area 4.82 cm2 vs 1.78 cm2, tenting volume 13.49 ml vs 4.27 ml. For LASr, mean values were 10.26 in patients with dilated cardiomyopathy vs 32.14 in healthy volunteers. Mean values of mitral valve parameters and LASr were comparable in ischemic vs non-ischemic cardiomyopathy patients. 3. LASr correlated with anatomical mitral valve parameters: annulus area: r=−0.6, annulus perimeter: r=−0.57, AP diameter: r=−0.58, PM-AL diameter: r=−0.58, commissural diameter: r=−0.66, inter-trigonal distance: r=−0.57, tenting height r=−0.53, tenting area r=−0.55 and tenting volume r=−0.54. Conclusions 1. In patients with dilated cardiomyopathy phenotype, anatomical parameters of the mitral valve and LASr were altered. Results did not reveal significant differences between ischemic and non-ischemic etiology. 2. A correlation was found between the decrease in LASr and anatomical parameters of the mitral valve, suggesting a link between atrial function deterioration and deformity of mitral apparatus geometry in patients with dilated cardiomyopathy. Funding Acknowledgement Type of funding sources: None.

Funding Acknowledgements Type of funding sources: None. Background Left atrial (LA) dimension is a marker of LV filling pressure, reflecting the severity and chronicity of diastolic dysfunction. LA is a stable parameter that combines chronic cardiovascular conditions effects and acute increase in filling pressure in acute myocardial infarction. Patients with acute coronary syndrome and increased left atrial volume index (LAVI) have a worse long-term prognosis. In patients with hypertension and diabetes, an increase in the LA dimension predicts cardiovascular events. There are limiting data about the impact of LAVI on the outcome in diabetic hypertensive patients with ST-elevation myocardial infarction (STEMI). Purpose: of the study was to compare LAVI in diabetic and nondiabetic hypertensive patients admitted with STEMI. Methods: ninety-eight hypertensive patients admitted with STEMI were enrolled, sixty-seven with diabetes mellitus and thirty-one without diabetes. The patients with atrial fibrillation and significant valvular disease were not included in the study. The evaluation consisted in clinical examination, echocardiographic measurements, laboratory tests, and 12 leads electrocardiography. 2D Echocardiography area-length technique was used for LA volume measurement. The LA endocardial borders were traced in both the apical four- and two-chamber views, and the results were body surface area indexed. The cut of value was 34ml/m2.  The Devereaux formula determined left ventricle mass index (LVMI), and the ranges were: 125 kg/m2 for males and 95 mg/m2 for females. Left ventricle ejection fraction (LVEF) was < 50% in all cases. Measurements were obtained in the first week after STEMI. The patients were divided into two groups: the first was between 40 and 60 years and the second was above 60 years. According to the age group, mean values (MV) and standard deviation (SD) were calculated, obtaining a comparison between diabetic and nondiabetic patients. Results: LAVI had higher values in diabetic patients: MV: 37.37 (SD: 3.39, CV: 9.07%) compare with nondiabetic patients: MV: 31.07 (SD: 2.67, CV 8.59%), p < 0.0001. Between 40-60 years LAVI MV were 36.43 +/- 3.21 in diabetic patients vs. 29.62+/-1.89 in nondiabetic patients (p = 0.0001); above 60 years of age LAVI MV were: 38.99 +/- 3.04 in diabetic patients and 31.14 +/- 2.8 in nondiabetics patients (p < 0.0001). In both group of age LAVI also correlated with body mass index, LVMI, LV volumes, LV diastolic dysfunction, LVEF, dyslipidemia and smoking. Conclusions: 1. In hypertensive patients admitted with STEMI, diabetes mellitus was an additional factor contributing to increased left atrium dimensions. 2. This study showed a correlation between LAVI and other factors involved in increasing LV filling pressure in hypertensive diabetic patients admitted with STEMI, underlying the importance of LA enlargement evaluation. Further studies with a larger number of patients are need to confirm these results.