The ongoing digital transformation of the economic and social life of society has led to a change in the models of competence development, which are based on systematic knowledge about the nature of digital technologies, cloud computing and cognitive technologies, Big Data technologies, Internet of Things and "SMM-promotion". In the course of the study, the list of key competencies was defined and systematized which are in demand in the context of economy digitalization; additional competencies for specialists with a managerial position were identified; the list of significant features of the digital economy in the agricultural sector was expanded. It is noted that the interrelation and interdependence of social and technical processes of agrarian production determine the formation of hybrid competencies associated with the ability to analyze the impact of technological trends on the business processes taking into account industry-specific features; develop and implement solutions for digital transformation of production taking into account environmental and social risks of digitalization. Evidence-based analysis of empirical data obtained during online testing confirmed the relevance of the proposed digital competencies and revealed the majority of respondents' incompetence (except for IT-specialists) in the field of digital technologies application. The obtained results confirm the need to update the content of higher education professional educational programs and professional development of teaching staff in accordance with the needs of digital economy and can become a starting point for the development of continuous training system of industry professionals for the digital economy.

The nigrostriatal system composed of the dorsal striatum and the substantia nigra (SN) is highly involved in the control of motor behavior. Various extremal and pathological conditions as well as social isolation may cause an impairment of locomotor function; however, corresponding alterations in the nigrostriatal dopaminergic pathway are far from full understanding. Here we analyzed the effect of 3-day hindlimb unloading (HU) and social isolation (SI) on the key players of dopamine transmission in the nigrostriatal system of CD1 mice. Three groups of mice were analyzed: group-housed (GH), SI, and HU. Our data showed a significant decrease in the expression of tyrosine hydroxylase (TH) in the SN and dorsal striatum of HU mice, but only in comparison with SI group that suggested attenuation of dopamine synthesis in response to HU, while TH phosphorylation was reduced in comparison with both GH and SI animals. SI also led to a decrease in TH phosphorylation in the dorsal striatum that pointed on an impact of isolation too. Expression of dopamine receptors D1 in the dorsal striatum of HU mice was increased suggesting a compensatory response, but the activity of downstream signaling pathways involving PKA and CREB was inhibited. But in the dorsal striatum of SI mice, expression of DA receptors and activity of downstream signaling was not affected. Obtained data let us to conclude that combination of short-term HU and isolation impaired dopamine transmission in the nigrostriatal system.