Pulmonary fibrosis is becoming a recognized complication of coronavirus disease 2019 (COVID-19). Patients with pulmonary fibrosis may present with dry cough, shortness of breath, nail clubbing, low oxygen saturation. We report a case of a 40-year-old male patient with pulmonary fibrosis due to COVID- 19. Clinical examination showed that the patient was dyspneic with low oxygen saturation and there was bilateral inspiratory crepitation in the lower part of his chest. High resolution computed tomography showed bilateral multifocal patchy ground-glass opacities, consolidation with peripheral and basal distribution, sub-pleural fibrotic bands and vascular thickening (almost 40-45% of parenchymal involvement). We prescribed him an antifibrotic drug, nintedanib and there was a significant clinical and radiological improvement after 15 days of treatment. Nintedanib may have novel therapeutic role in preventing COVID-19 associated fibrosis. Birdem Med J 2021; 11(2): 148-152

Background and Aims Inhalation of respirable silica dust during several stone processing methods can result in several respiratory diseases. However, data are scarce regarding the respiratory health of stone‐cutting workers in Bangladesh. We aimed to determine the point prevalence of respiratory symptoms, lung function status and radiological abnormalities among the stone‐cutting workers. Methods This cross‐sectional study was conducted among 200 stone‐cutting workers. Adult workers having a job experience of at least 3 years participated in this study. Then inquiry was made regarding respiratory symptoms with the help of a preformed questionnaire. All the participants underwent chest X‐ray and spirometry. A respiratory dust sampler was used to measure the dust concentration of the stone‐cutting factories. Results Among the 200 stone‐cutting workers, 89% (178) showed at least one chronic respiratory symptom while they had chest tightness (75.5%), chronic cough (74.5%), and shortness of breath (66.5%) as the most prominent ones. Spirometry findings revealed that the mean forced expiratory volume in 1 s (FEV 1 ) value was 1.42± 0.65 L in the obstructive pattern, 1.43 ± 0.73 L in the restrictive pattern. The mean forced vital capacity (FVC) value was 2.53 ± 1.12 L in the obstructive pattern, 1.53 ± 0.75 L in the restrictive pattern. 42.69% of stone‐cutting workers who complained of at least one respiratory symptom had abnormal chest X‐ray findings. Those with progressive massive fibrosis had the lowest mean FEV 1 value (0.75 ± 0.50 L). While measuring workplace dust concentration, we found high particulate matter (PM) 2.5 (979.78 µg/m 3 ) and PM 10 (1298.35 µg/m 3 ) values. Conclusions Most of the stone‐cutting workers in our study exhibited different respiratory symptoms. These symptoms were associated with abnormal lung function and radiology. Further longitudinal studies are recommended to determine the actual dimension of this problem.

Multiple myeloma is a malignant proliferation of plasma cells that typically presents in the bone marrow.Extramedullaryplasmacytoma (EMP) represents an unusual and characteristically progressive malignancythat can arise outside the bone marrow. The occurrence of multiple myeloma with plasmacytoma of thelung is very unusual. Herein, we report a case of multiple myeloma with plasmacytoma of the lungdiagnosed by CT-guided FNAC and bone marrow trephine biopsy. J MEDICINE 2022; 23: 96-100

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