The LoS Alamos VBatrOna &oratory requests that the publisher identify this article as work performed under the auspices of the U.S. Department of Energy. F o n No. 836 R5 ST 2629 1 US1 ~~~~~ OF w llcnM%r Is C I P K f M m DISCLAIMER Portions of this document may be illegible in electronic image products. Images are produced from the best available h original document. DISCLAIMER This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, reammendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof.

No abstract

This is the final report of a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL,). Hydrophobic effects are central to the structural stability of biomolecules, particularly proteins, in solution but are not understood at a molecular level. This project developed a new theoretical approach to calculation of hydrophobic effects. This information theory approach can be implemented with experimental, including computer simulationexperimental, information. The new theory is consistent with, builds upon, and subsumes previous integral equation and scaled particle statistical thermodynamic models of hydrophobic effects. The new theory is sufficiently simple to permit application directly to complex biomolecules in solution and to permit further extension to incorporate more subtle effects. Background and Research Objectives