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Drugs of the sulfonamide type have recently been extensively investigated as antimalarials. As part of this general program the compounds in Table I were prepared.3As intermediates, several unreported aniline derivatives were required and their preparation is also described.These compounds were prepared by coupling an appropriate sulfonyl chloride with the required aniline derivative and hydrolyzing or reducing the product to the final compound. The method of coupling and hydrolysis employed was essentially that of Long and Burger (1), but it was found that variations in the experimental details were of great importance in obtaining satisfactory yields of the products.

1. The use of phosphorus oxybromide as a reagent for the bromination of hydroxypyrimidines is reported.2. A number of new bromopyrimidines, with bromine in the 2, 4, and 6positions are reported. Pasadena, Calif.