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Reformatsky reactions between 2,3-dihydro-4(1H)-phenanthrenone (5) and ethyl alpha-bromoacetate or propanoate yield several unsaturated esters which, upon aromatization followed by saponification, lead to the 4-phenanthrylacetic (1) and 2-(4-phenanthryl)propanoic (2) acids. The analgesic and anti-inflammatory properties of 1 and 2 were measured and compared with those of Fenbufen.

Reformatsky reactions between 3.4‐dihydro‐1(2H)‐phenanthrenone (5) and ethyl α‐bromoacetate or propanoate yield several unsaturated esters which, upon aromatization followed by saponification, lead to the 1‐phenanthrylacetic (1) and 2‐(1‐phenanthryl)propanoic (2) acids, whose analgesic and anti‐inflammatory properties were measured and found comparable to those of Fenbufen.