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The circular economy in agriculture aims to reduce waste while also making best use of residues by using economically viable processes and procedures to increase their value. In this study a two-level cascade cultivation system was set up under greenhouse conditions. The research was focused on the identification of crop species as secondary crops and the development/iterative optimization of cultivation practices. For this purpose, different crop-combinations with a primary and different secondary crops were investigated using different system-layouts. Measurements were carried out during two cultivation periods. During the 1st Period a combination of cucumber (Cucumis sativus) as primary crop, with rosemary (Rosmarinus officinalis), basil (Ocimum basilicum), and peppermint (Mentha piperita) as secondary crops, was evaluated. In the 2nd Period the drainage of tomato (Solanum lycopersicum) plants was re-used to irrigate spearmint (Mentha spicata), dill (Anethum graveolens), celery (Apium graveolens) and parsley (Petroselinum crispum) plants. In both periods, different fertigation management strategies based on the drainage solution of the primary crop were employed. The use of the cascade hydroponic system improved both crop water and nutrient use efficiency. Notably, the NO3 disposal was about 40% less as compared to a monoculture. Average fresh water consumption of secondary crop plants irrigated with diluted drainage solution was reduced by 30% in comparison to plants irrigated with fresh water.

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