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Introduction: Fulminant hepatitis is a very rare disease that occurs as an acute liver failure within eight weeks of the onset of symptoms following hepatitis A in adults or in patients with a history of chronic hepatitis B or C [1]. Case presentation: There were three cases in this research. The first case was a self-employed male patient aged 26 years from Gaz Borkhar, admitted to Al-Zahral Hospital on January 1, 2016 for fever, chills and vomiting. The second patient was a 20-year-old male athlete from Lenjan and was hospitalized on May 3, 2016 for fever, chills, anorexia, yellowing of the skin, and low consciousness. The third case was a 20-year-old male employee from Isfahan who visited Al-Zahra Hospital for developing nausea, vomiting, and discolored urine, followed by icterus. Conclusion: all patients were young without any underlying disease. Although the disease had a very progressive course leading to coma, all cases fortunately survived through supportive measures and returned to their normal lives.

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