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In subcutaneous human tissue of obese and non obese subjects glucose uptake and incorporation of g1ucos~I)4C into CO2 were measured after incubation in a medium containing glucose. Basal glucose uptake was not correlated to age and body weight and was not changed in obese subjects. Insulin caused a significant increase of glucose uptake and a less marked increase of glucose oxydation. There was a lin~ ar relationship between the percentual increase of glucose uptake and the log of insulin dose. The maximal effective insulin concentration was 1000 pE/mi, higher doses did not cause further increase of glucose uptake.